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Effect of apomorphine on the antinociceptive activity of morphine

Effect of apomorphine on the antinociceptive activity of morphine 213 53 53 1 1 Zsuzsa Dunai-Kovács J. I. Székely Research Institute for Pharmaceutical Chemistry P.O. Box 82 H-1325 Budapest Hungary Abstract Apomorphine pretreatment potentiated the analgesic effect of morphine in a dose-dependent manner both in rats and in mice measured by five different tests (writhing, hot plate, inflamed foot, tail-pinch and tail-flick procedures). Furthermore, apomorphine augmented the antinociceptive activity of morphine in tolerant animals as well. In morphine dependent mice the nalorphine precipitated jumping—a withdrawal symptom—was found inhibited by apomorphine treatment. The results are discussed in the light of the numerous but contradictory data available in the literature. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effect of apomorphine on the antinociceptive activity of morphine

Psychopharmacology , Volume 53 (1) – Jan 1, 1977

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References (56)

Publisher
Springer Journals
Copyright
Copyright © 1977 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00426695
Publisher site
See Article on Publisher Site

Abstract

213 53 53 1 1 Zsuzsa Dunai-Kovács J. I. Székely Research Institute for Pharmaceutical Chemistry P.O. Box 82 H-1325 Budapest Hungary Abstract Apomorphine pretreatment potentiated the analgesic effect of morphine in a dose-dependent manner both in rats and in mice measured by five different tests (writhing, hot plate, inflamed foot, tail-pinch and tail-flick procedures). Furthermore, apomorphine augmented the antinociceptive activity of morphine in tolerant animals as well. In morphine dependent mice the nalorphine precipitated jumping—a withdrawal symptom—was found inhibited by apomorphine treatment. The results are discussed in the light of the numerous but contradictory data available in the literature.

Journal

PsychopharmacologySpringer Journals

Published: Jan 1, 1977

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