To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impair- ment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features. Keywords Autism spectrum disorder · Biomarker · Epileptiform abnormalities · Hyperactivity · Phenotype Introduction Compared with the healthy population, patients with ASD have an increased incidence of epilepsy (2–3% vs. 5–46%, Autism spectrum disorder (ASD) is a neurodevelopment dis- respectively) (Hughes and Melyn 2005; Tuchman and Rapin order characterized by a persistent impairment of communi- 2002). Moreover, studies show a higher risk of autism in cation and social interaction as well as restricted, repetitive patients suffering from specific forms of epilepsy such as and stereotyped behaviors (American Psychiatric
Journal of Autism and Developmental Disorders – Springer Journals
Published: Feb 5, 2019
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