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Dynamic Changes of Matrix Metalloproteinase-9 in Patients with Klebsiella pneumoniae Meningitis

Dynamic Changes of Matrix Metalloproteinase-9 in Patients with Klebsiella pneumoniae Meningitis To quantitate cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase 9 (MMP-9) in adult patients with Klebsiella pneumoniae meningitis and to correlate levels of MMP-9 with parameters of intrathecal inflammation and analyze the kinetic changes of MMP-9. In a prospective cohort study, levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP-1) concentrations were measured in the CSF of six adult patients with meningitis and 11 controls. MMP-9 and TIMP-1 were detected in all of the six patients at presentation and follow up lumbar puncture. CSF levels of MMP-9 (6.71 ± 7.29 ng/ml) and TIMP-1(454.3 ± 242.9 ng/ml) were higher in patients than in the control group (0.07 ± 0.11 ng/ml and 27.14 ± 39.34 ng/ml, respectively). Levels of MMP-9 correlated with CSF concentrations of protein, cell count and lactate. Repeated lumbar punctures showed that levels of MMP-9 decrease during clinical recovery, although the levels of MMP-9 in the CSF are variable because of the small number of cases. The relative change in gelatin zymography is comparable to the changes of MMP-9 levels found in ELISA. MMP-9 levels in CSF may be a useful tool in follow-up in patients with K. pneumoniae meningitis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Inflammation Springer Journals

Dynamic Changes of Matrix Metalloproteinase-9 in Patients with Klebsiella pneumoniae Meningitis

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References (32)

Publisher
Springer Journals
Copyright
Copyright © Springer Science+Business Media, LLC 2008
Subject
Medicine & Public Health; Pathology ; Pharmacology/Toxicology ; Internal Medicine ; Rheumatology
ISSN
0360-3997
eISSN
1573-2576
DOI
10.1007/s10753-008-9071-5
pmid
18553165
Publisher site
See Article on Publisher Site

Abstract

To quantitate cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase 9 (MMP-9) in adult patients with Klebsiella pneumoniae meningitis and to correlate levels of MMP-9 with parameters of intrathecal inflammation and analyze the kinetic changes of MMP-9. In a prospective cohort study, levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP-1) concentrations were measured in the CSF of six adult patients with meningitis and 11 controls. MMP-9 and TIMP-1 were detected in all of the six patients at presentation and follow up lumbar puncture. CSF levels of MMP-9 (6.71 ± 7.29 ng/ml) and TIMP-1(454.3 ± 242.9 ng/ml) were higher in patients than in the control group (0.07 ± 0.11 ng/ml and 27.14 ± 39.34 ng/ml, respectively). Levels of MMP-9 correlated with CSF concentrations of protein, cell count and lactate. Repeated lumbar punctures showed that levels of MMP-9 decrease during clinical recovery, although the levels of MMP-9 in the CSF are variable because of the small number of cases. The relative change in gelatin zymography is comparable to the changes of MMP-9 levels found in ELISA. MMP-9 levels in CSF may be a useful tool in follow-up in patients with K. pneumoniae meningitis.

Journal

Inflammation – Springer Journals

Published: Aug 1, 2008

Keywords: gelatin zymography; Klebsiella pneumoniae; matrix metalloproteinase 9; meningitis

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