Eur J Drug Metab Pharmacokinet https://doi.org/10.1007/s13318-018-0460-3 SHORT COMMUNICATION Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation 1 1 1 • • Willi Cawello Marina Braun Jens-Otto Andreas Springer International Publishing AG, part of Springer Nature 2018 Abstract patients with PD, absorption was constant during patch-on Background and Objective Pharmacokinetic studies using periods and resembled zero-order kinetics. deconvolution methods and non-compartmental analysis to Conclusion Deconvolution based on rotigotine pharma- model clinical absorption of drugs are not well represented cokinetic proﬁles after single- or multiple-dose adminis- in the literature. The purpose of this research was (1) to tration of the once-daily patch demonstrated that in vivo deﬁne the system of equations for description of rotigotine absorption of rotigotine showed constant input through the (a dopamine receptor agonist delivered via a transdermal skin into the central circulation (resembling zero-order patch) absorption based on a pharmacokinetic model and kinetics). Continuous absorption through the skin is a basis (2) to describe the kinetics of rotigotine disposition after for stable drug exposure. single and multiple dosing. Methods The kinetics of drug disposition was evaluated based on rotigotine plasma concentration data from
European Journal of of Drug Metabolism and Pharmacokinetics – Springer Journals
Published: Jan 13, 2018
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