Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation

Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo... Eur J Drug Metab Pharmacokinet https://doi.org/10.1007/s13318-018-0460-3 SHORT COMMUNICATION Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation 1 1 1 • • Willi Cawello Marina Braun Jens-Otto Andreas Springer International Publishing AG, part of Springer Nature 2018 Abstract patients with PD, absorption was constant during patch-on Background and Objective Pharmacokinetic studies using periods and resembled zero-order kinetics. deconvolution methods and non-compartmental analysis to Conclusion Deconvolution based on rotigotine pharma- model clinical absorption of drugs are not well represented cokinetic profiles after single- or multiple-dose adminis- in the literature. The purpose of this research was (1) to tration of the once-daily patch demonstrated that in vivo define the system of equations for description of rotigotine absorption of rotigotine showed constant input through the (a dopamine receptor agonist delivered via a transdermal skin into the central circulation (resembling zero-order patch) absorption based on a pharmacokinetic model and kinetics). Continuous absorption through the skin is a basis (2) to describe the kinetics of rotigotine disposition after for stable drug exposure. single and multiple dosing. Methods The kinetics of drug disposition was evaluated based on rotigotine plasma concentration data from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of of Drug Metabolism and Pharmacokinetics Springer Journals

Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation

Loading next page...
 
/lp/springer-journals/drug-delivery-and-transport-into-the-central-circulation-an-example-of-096CopL0Oi
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Human Physiology; Pharmaceutical Sciences/Technology; Medical Biochemistry
ISSN
0378-7966
eISSN
2107-0180
D.O.I.
10.1007/s13318-018-0460-3
Publisher site
See Article on Publisher Site

Abstract

Eur J Drug Metab Pharmacokinet https://doi.org/10.1007/s13318-018-0460-3 SHORT COMMUNICATION Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation 1 1 1 • • Willi Cawello Marina Braun Jens-Otto Andreas Springer International Publishing AG, part of Springer Nature 2018 Abstract patients with PD, absorption was constant during patch-on Background and Objective Pharmacokinetic studies using periods and resembled zero-order kinetics. deconvolution methods and non-compartmental analysis to Conclusion Deconvolution based on rotigotine pharma- model clinical absorption of drugs are not well represented cokinetic profiles after single- or multiple-dose adminis- in the literature. The purpose of this research was (1) to tration of the once-daily patch demonstrated that in vivo define the system of equations for description of rotigotine absorption of rotigotine showed constant input through the (a dopamine receptor agonist delivered via a transdermal skin into the central circulation (resembling zero-order patch) absorption based on a pharmacokinetic model and kinetics). Continuous absorption through the skin is a basis (2) to describe the kinetics of rotigotine disposition after for stable drug exposure. single and multiple dosing. Methods The kinetics of drug disposition was evaluated based on rotigotine plasma concentration data from

Journal

European Journal of of Drug Metabolism and PharmacokineticsSpringer Journals

Published: Jan 13, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off