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M Gharanei, A Hussain, O Janneh, HL Maddock (2013)
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition poreToxicology and Applied Pharmacology, 268
KB Wallace (2007)
Adriamycin-induced interference with cardiac mitochondrial calcium homeostasisCardiovascular Toxicology, 7
R Shi, CC Huang, RS Aronstam, N Ercal, A Martin, YW Huang (2009)
N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytesBMC Pharmacology, 9
MA Abd El-Aziz, AI Othman, M Amer, MA El-Missiry (2001)
Potential protective role of angiotensin-converting enzyme inhibitors captopril and enalapril against adriamycin-induced acute cardiac and hepatic toxicity in ratsJournal of Applied Toxicology, 21
A Kalvelyte, A Imbrasaite, A Bukauskiene, VK Verselis, FF Bukauskas (2003)
Connexins and apoptotic transformationBiochemical Pharmacology, 66
Y Octavia, CG Tocchetti, KL Gabrielson, S Janssens, HJ Crijns, AL Moens (2012)
Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategiesJournal of Molecular and Cellular Cardiology, 52
A Rodriguez-Sinovas, K Boengler, A Cabestrero, P Gres, M Morente, M Ruiz-Meana, I Konietzka, E Miró, A Totzeck, G Heusch, R Schulz, D Garcia-Dorado (2006)
Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotectionCirculation Research, 99
G Lu, HK Haider, A Porollo, M Ashraf (2010)
Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cellsCardiovascular Research, 88
P Rehling, K Brandner, N Pfanner (2004)
Mitochondrial import and the twin-pore translocaseNature Reviews Molecular Cell Biology, 5
PS Green, C Leeuwenburgh (2002)
Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosisBiochimica et Biophysica Acta, 1588
AP Halestrap (2006)
Mitochondria and preconditioning: A connexin connection?Circulation Research, 99
L Chaiswing, MP Cole, DK St Clair, W Ittarat, LI Szweda, TD Oberley (2004)
Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injuryToxicologic Pathology, 32
A Rodríguez-Sinovas, A Cabestrero, D López, I Torre, M Morente, A Abellán, E Miró, M Ruiz-Meana, D García-Dorado (2007)
The modulatory effects of connexin 43 on cell death/survival beyond cell couplingProgress in Biophysics and Molecular Biology, 94
BW Doble, X Dang, P Ping, RR Fandrich, BE Nickel, Y Jin, PA Cattini, E Kardami (2004)
Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell–cell contact forming cardiomyocytesJournal of Cell Science, 117
F Goubaeva, M Mikami, S Giardina, B Ding, J Abe, J Yang (2007)
Cardiac mitochondrial connexin 43 regulates apoptosisBiochemical and Biophysical Research Communications, 352
T Azarashvili, Y Baburina, D Grachev, O Krestinina, Y Evtodienko, R Stricker, G Reiser (2011)
Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43American Journal of Physiology. Cell Physiology, 300
K Boengler, R Schulz, G Heusch (2006)
Connexin 43 signalling and cardioprotectionHeart, 92
Y Ichikawa, M Ghanefar, M Bayeva, R Wu, A Khechaduri, SV Naga Prasad, RK Mutharasan, TJ Naik, H Ardehali (2014)
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulationThe Journal of Clinical Investigation, 124
JM Berthiaume, KB Wallace (2007)
Adriamycin-induced oxidative mitochondrial cardiotoxicityCell Biology and Toxicology, 23
K Trudeau, T Muto, S Roy (2012)
Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome C release in retinal endothelial cellsInvestigative Ophthalmology & Visual Science, 53
LI Plotkin, SC Manolagas, T Bellido (2002)
Transduction of cell survival signals by connexin-43 hemichannelsJournal of Biological Chemistry, 277
M Ruiz-Meana, A Rodríguez-Sinovas, A Cabestrero, K Boengler, G Heusch, D Garcia-Dorado (2008)
Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injuryCardiovascular Research, 77
K Boengler (2009)
Stimulation of cardiac beta-adrenoceptors targets connexin 43British Journal of Pharmacology, 158
T Sakurai, M Tsuchida, PD Lampe, M Murakami (2013)
Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenanceExperimental Cell Research, 319
A Popolo, S Morello, R Sorrentino, A Pinto (2013)
Antiadrenergic effect of adenosine involves connexin 43 turn-over in H9c2 cellsEuropean Journal of Pharmacology, 715
T Improta-Brears, AR Whorton, F Codazzi, JD York, T Meyer, DP McDonnell (1999)
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calciumProceedings of the National Academy of Sciences of the United States of America, 96
SV Kalivendi, EA Konorev, S Cunningham, SK Vanamala, EH Kaji, J Joseph, B Kalyanaraman (2005)
Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calciumBiochemical Journal, 389
Doxorubicin is the highly effective anthracycline, but its clinical use is limited by cardiotoxicity and consequent dysfunction. It has been proposed that the etiology of this is related to mitochondrial dysfunction. Connexin 43 (Cx43), the principal protein building block of cardiac gap junctions and hemichannels, plays an important role in cardioprotection. Recent reports confirmed the presence of Cx43 in the mitochondria as well. In this study, the role of mitochondrial Cx43 was evaluated 3 or 6 h after Doxorubicin administration to the rat heart cell line H9c2. Pharmacological inhibition of Hsp90 demonstrated that the mitochondrial Cx43 conferred cardioprotection by reducing cytosolic and mitochondrial reactive oxygen species production, mitochondrial calcium overload and mitochondrial membrane depolarization and cytochrome c release. In conclusion, our study demonstrates that Cx43 plays an important role in the protection of cardiac cells from Doxorubicin-induced toxicity.
Cardiovascular Toxicology – Springer Journals
Published: Jan 1, 2015
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