Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine

Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with... 213 108 108 3 3 John H. Krystal Christopher J. McDougle Scott W. Woods Lawrence H. Price George R. Heninger Dennis S. Charney VA-yale Alcoholism Research Center Yale University School of Medicine, West Haven VA Medical Center 950 Campbell Avenue 06516 West Haven CT USA Clinical Neuroscience Research Unit Yale University School of Medicine, Connecticut Mental Health Center 34 Park Street 06519 New Haven CT USA Abstract The effects of oral administration of the α 2 adrenergic receptor antagonists idazoxan (20 mg, 40 mg, 80 mg) and yohimbine (20 mg) were compared using a placebo-controlled within-subjects design. Healthy subjects completed 5 test days during which medication effects on mood and anxiety states, physiologic indices, plasma cortisol levels, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were assessed. Idazoxan dose-dependently increased plasma MHPG, plasma cortisol, systolic and diastolic blood pressure, and Panic Attack Symptom Scale scores in healthy subjects. Overall, yohimbine and idazoxan produced a similar pattern of behavioral and neuroendocrine responses. Since idazoxan possesses relatively greater receptor specificity compared to yohimbine, it may be a more useful α 2 antagonist in humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine

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Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245117
Publisher site
See Article on Publisher Site

Abstract

213 108 108 3 3 John H. Krystal Christopher J. McDougle Scott W. Woods Lawrence H. Price George R. Heninger Dennis S. Charney VA-yale Alcoholism Research Center Yale University School of Medicine, West Haven VA Medical Center 950 Campbell Avenue 06516 West Haven CT USA Clinical Neuroscience Research Unit Yale University School of Medicine, Connecticut Mental Health Center 34 Park Street 06519 New Haven CT USA Abstract The effects of oral administration of the α 2 adrenergic receptor antagonists idazoxan (20 mg, 40 mg, 80 mg) and yohimbine (20 mg) were compared using a placebo-controlled within-subjects design. Healthy subjects completed 5 test days during which medication effects on mood and anxiety states, physiologic indices, plasma cortisol levels, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were assessed. Idazoxan dose-dependently increased plasma MHPG, plasma cortisol, systolic and diastolic blood pressure, and Panic Attack Symptom Scale scores in healthy subjects. Overall, yohimbine and idazoxan produced a similar pattern of behavioral and neuroendocrine responses. Since idazoxan possesses relatively greater receptor specificity compared to yohimbine, it may be a more useful α 2 antagonist in humans.

Journal

PsychopharmacologySpringer Journals

Published: Aug 1, 1992

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