Bone Marrow Transplantation (2018) 53:352–355 https://doi.org/10.1038/s41409-017-0037-9 CORRESPONDENCE Donor derived T-cell large granular lymphocyte leukemia after cord blood transplant for pediatric T-cell lymphoblastic leukemia 1 2 2 2 3 2 ● ● ● ● ● ● Tyler G. Ketterl David Wu Jonathan R. Fromm Lorinda Soma Ann E. Dahlberg Brent L. Wood Katherine Tarlock Received: 5 September 2017 / Revised: 29 September 2017 / Accepted: 2 October 2017 / Published online: 21 December 2017 © Macmillan Publishers Limited, part of Springer Nature 2018 Large granular lymphocyte (LGL) leukemia is characterized cyclophosphamide and total body irradiation (13.2 Gy) by a clonal expansion of either CD3(+) cytotoxic T or with cranial boost. Graft versus host disease (GVHD) CD3(−) NK cells. LGL leukemia most commonly affects prophylaxis included cyclosporine and mycophenolate the elderly with a median age of 60, although cases in mofetil. Early post-transplant, the patient developed acute younger adults and very rarely pediatric patients have been skin grade IIB GVHD which was treated with high-dose reported [1–4]. In most cases T-LGL leukemia is associated prednisone. Following completion of an initial prednisone with an indolent clinical course characterized by cytopenias taper, she developed delayed acute gastrointestinal GVHD grade IIA that was treated
Bone Marrow Transplantation – Springer Journals
Published: Dec 21, 2017
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