Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Oesterling, J. Epstein, P. Walsh (1986)
The inability of adrenal androgens to stimulate the adult human prostate: an autopsy evaluation of men with hypogonadotropic hypogonadism and panhypopituitarism.The Journal of urology, 136 5
P. Agarwal, M. Oefelein (2005)
Testosterone replacement therapy after primary treatment for prostate cancer.The Journal of urology, 173 2
White Jw (1895)
I. The Results of Double Castration in Hypertrophy of the Prostate.Annals of Surgery, 22
A. Hsing, J. Reichardt, F. Stanczyk (2002)
Hormones and prostate cancer: Current perspectives and future directionsThe Prostate, 52
D. Coffey, P. Walsh (1990)
Clinical and experimental studies of benign prostatic hyperplasia.The Urologic clinics of North America, 17 3
Claus Roehrborn, Peter Boyle, A.Lawrence Gould, J. Waldstreicher (1999)
Serum prostate-specific antigen as a predictor of prostate volume in men with benign prostatic hyperplasia.Urology, 53 3
J. Hunter (1841)
The Complete Works of John Hunter
M. Algarte-Genin, O. Cussenot, P. Costa (2004)
Prevention of prostate cancer by androgens: experimental paradox or clinical reality.European urology, 46 3
J. Eastham, E. Riedel, P. Scardino, M. Shike, M. Fleisher, A. Schatzkin, E. Lanza, L. Latkany, C. Begg (2003)
Variation of serum prostate-specific antigen levels: an evaluation of year-to-year fluctuations.JAMA, 289 20
R. Svatek, M. Shulman, E. Benaim, T. Rogers, V. Margulis (2008)
Change in prostate specific antigen following androgen stimulation is an independent predictor of prostate cancer diagnosis.The Journal of urology, 179 6
F. Gaylis, D. Lin, J. Ignatoff, C. Amling, R. Tutrone, D. Cosgrove (2005)
Prostate cancer in men using testosterone supplementation.The Journal of urology, 174 2
J. Kaufman, R. Graydon (2004)
Androgen replacement after curative radical prostatectomy for prostate cancer in hypogonadal men.The Journal of urology, 172 3
D. Hessels, J. Gunnewiek, I. Oort, H. Karthaus, G. Leenders, Bianca Balken, L. Kiemeney, J. Witjes, J. Schalken (2003)
DD3PCA3-based Molecular Urine Analysis for the Diagnosis of Prostate CancerEuropean Urology, 44
T. Imamoto, Hiroyoshi Suzuki, S. Fukasawa, M. Shimbo, Masahiko Inahara, A. Komiya, T. Ueda, T. Shiraishi, T. Ichikawa (2005)
Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy.European urology, 47 3
E.L. Rhoden, A. Morgentaler (2004)
Risks of testosterone-replacement therapy and recommendations for monitoringN Engl J Med, 350
J. Fowler, W. Whitmore (1981)
The response of metastatic adenocarcinoma of the prostate to exogenous testosterone.The Journal of urology, 126 3
J. Tenover (2000)
Experience with testosterone replacement in the elderly.Mayo Clinic proceedings, 75 Suppl
J. Hunter, R. Owen (1839)
Observations on Certain Parts of the Animal Economy, Inclusive of Several Papers from the Philosophical Transactions, &c.The British and Foreign Medical Review, 7
A. Morgentaler, C. Bruning, W. DeWolf (1996)
Occult prostate cancer in men with low serum testosterone levels.JAMA, 276 23
J. Groskopf, S. Aubin, C. Clark, S. Brentano, Jeannette Mathis, Jimmykim Pham, Troels Meyer, M. Cass, Petrea Hodge, M. Macairan, L. Marks, H. Rittenhouse
Aptima Pca3 Molecular Urine Test: Development of a Method to Aid in the Diagnosis of Prostate Cancer
E. Rhoden, C. Riedner, A. Morgentaler (2008)
The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men.The Journal of urology, 179 5
L. Miller, A. Partin, D. Chan, D. Bruzek, A. Dobs, J. Epstein, P. Walsh (1998)
Influence of radical prostatectomy on serum hormone levels.The Journal of urology, 160 2
C. Huggins, R. Stevens (1940)
The Effect of Castration on Benign Hypertrophy of the Prostate in Man11This investigation was supported by a grant from the Committee on Research in Problems of Sex of the National Research Council.The Journal of Urology, 43
L. Marks, E. Mostaghel, P. Nelson (2008)
Prostate tissue androgens: history and current clinical relevance.Urology, 72 2
J. Imperato-McGinley, L. Guerrero, T. Gautier, Germanjuk Jl, Peterson Re (1975)
Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism.Science, 186 4170
C. Huggins, R. Stevens, C. Hodges (1941)
STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLANDArchives of Surgery, 43
M. Sarosdy (2007)
Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapyCancer, 109
MD Thompson, PhD Ankerst, MS Chi, M. Scott, MS Goodman, PhD Crowley, MD Parnes, J. COLTMAN, Ankerst Thompson, Mss Chi, Goodman, Ankerst Thompson, Coltman Parnes, Lucia Thompson, Chi Ankerst, Crowley. Goodman, Ankerst Thompson, Ankerst Thompson (2005)
Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower.JAMA, 294 1
J. Imperato-McGinley, L. Guerrero, T. Gautier, R. Peterson (1974)
Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male PseudohermaphroditismScience, 186
L. Marks, Y. Fradet, I. Deras, A. Blase, Jeannette Mathis, S. Aubin, Anthony Cancio, Marie Desaulniers, W. Ellis, H. Rittenhouse, J. Groskopf (2007)
PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy.Urology, 69 3
S. Balk, Y. Ko, G. Bubley (2003)
Biology of prostate-specific antigen.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21 2
M. Khera, L. Lipshultz (2007)
The role of testosterone replacement therapy following radical prostatectomy.The Urologic clinics of North America, 34 4
C. Huggins, R.A. Stevens (1940)
The effect of castration on benign hypertrophy of the prostate in manJ Urol, 43
G. Gormley, E. Stoner, R. Bruskewitz, J. Imperato-McGinley, P. Walsh, J. Mcconnell, G. Andriole, J. Geller, B. Bracken, J. Tenover (1992)
The effect of finasteride in men with benign prostatic hyperplasia.The Journal of urology, 149 4
G.J. Gormley, E. Stoner, R.C. Bruskewitz (1992)
The effect of finasteride in men with benign prostatic hyperplasia. The Finasteride Study GroupN Engl J Med, 327
M. Marberger, C. Roehrborn, L. Marks, T. Wilson, R. Rittmaster (2006)
Relationship among serum testosterone, sexual function, and response to treatment in men receiving dutasteride for benign prostatic hyperplasia.The Journal of clinical endocrinology and metabolism, 91 4
A. Roddam, N. Allen, P. Appleby, T. Key (2008)
Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies.Journal of the National Cancer Institute, 100 3
E. Rhoden, A. Morgentaler (2003)
Testosterone replacement therapy in hypogonadal men at high risk for prostate cancer: results of 1 year of treatment in men with prostatic intraepithelial neoplasia.The Journal of urology, 170 6 Pt 1
J. Parsons, H. Carter, E. Platz, E. Wright, P. Landis, E. Metter, J. Brady (2006)
UROLOGICAL ONCOLOGY: PROSTATE CANCER Serum Testosterone and the Risk of Prostate Cancer: Potential Implications for Testosterone Therapy
Wu Cp, Gu Fl (1991)
The prostate in eunuchs.Progress in Clinical and Biological Research, 370
L. Marks, N. Mazer, E. Mostaghel, D. Hess, F. Dorey, J. Epstein, R. Veltri, D. Makarov, A. Partin, D. Bostwick, M. Macairan, P. Nelson (2006)
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.JAMA, 296 19
E. Rhoden, A. Morgentaler (2004)
MEDICAL PROGRESS: RISKS OF TESTOSTERONE REPLACEMENT THERAPY AND RECOMMENDATIONS FOR MONITORING, 350
T. Shirai, S. Takahashi, L. Cui, M. Futakuchi, K. Kato, S. Tamano, K. Imaida (2000)
Experimental prostate carcinogenesis - rodent models.Mutation research, 462 2-3
D. Johnson, T. Haynie (1977)
Phosphorus-32 for intractable pain in carcinoma of prostate. Analysis of androgen priming, parathormone rebound, and combination therapy.Urology, 9 2
S. Bhasin, Atam Singh, R. Mac, Ballentine Carter, Martin Lee, G. Cunningham (2003)
Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan.Journal of andrology, 24 3
A. Magklara, A. Scorilas, A. Scorilas, A. Scorilas, C. Stephan, G. Kristiansen, Steffen Hauptmann, K. Jung, E. Diamandis, E. Diamandis, E. Diamandis (2000)
Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue.Urology, 56 3
Wael Sakr, David Grignon, Gabriel Haas, Lance Heilbrun, J. Pontes, John Crissmana (1996)
Age and racial distribution of prostatic intraepithelial neoplasia.European urology, 30 2
M. Dall’Era, M. Cooperberg, J. Chan, B. Davies, P. Albertsen, L. Klotz, C. Warlick, L. Holmberg, D. Bailey, Meredith Wallace, P. Kantoff, P. Carroll (2008)
Active surveillance for early‐stage prostate cancerCancer, 112
J.K. Parsons, H.B. Carter, E.A. Platz (2005)
Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapyCancer Epidemiol Biomarkers Prev, 14
M.A. Dall’Era, M.R. Cooperberg, J.M. Chan (2008)
Active surveillance for early-stage prostate cancer: review of the current literatureCancer, 112
Millions of men are candidates for testosterone replacement therapy (TRT), but a major safety concern, the effects of TRT on the prostate, has been poorly understood until recently. In the past few years, a meta-analysis showed that endogenous hormone levels have little relationship to prostate cancer. Another review showed that during TRT, cancer develops with no more frequency than in the overall population. A randomized trial focusing on TRT’s tissue effects showed that no treatment-related change was noted in prostate tissue composition, hormone levels, biomarkers, gene expression, or cancer incidence. And in animal models, testosterone alone is at most only a weak prostatic carcinogen. Thus, recent years have seen clarification of the prostate safety issue. Future areas of interest include using TRT in men believed to be cured of prostate cancer and, importantly, developing cancer-specific biomarkers (eg, PCA3 gene) to help diagnose and monitor men receiving TRT.
Current Sexual Health Reports – Springer Journals
Published: Nov 25, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.