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DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human... Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction. We conducted a systematic review of 47 recent (2012–2015) animal and human studies that investigate DNA methylation and substance use/exposure, spanning preconception to adulthood. The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional. While studies generally support an association between substance use/exposure and DNA methylation and also suggest that developmental context and timing matter, a dearth of longitudinal data and low comparability across studies currently limits the conclusions that can be drawn. Future challenges and directions for the field are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Addiction Reports Springer Journals

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer International Publishing AG
Subject
Medicine & Public Health; Psychiatry; Neurology
eISSN
2196-2952
DOI
10.1007/s40429-015-0072-9
Publisher site
See Article on Publisher Site

Abstract

Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction. We conducted a systematic review of 47 recent (2012–2015) animal and human studies that investigate DNA methylation and substance use/exposure, spanning preconception to adulthood. The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional. While studies generally support an association between substance use/exposure and DNA methylation and also suggest that developmental context and timing matter, a dearth of longitudinal data and low comparability across studies currently limits the conclusions that can be drawn. Future challenges and directions for the field are discussed.

Journal

Current Addiction ReportsSpringer Journals

Published: Sep 28, 2015

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