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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Springer-Verlag
- Subject
- Medicine
- ISSN
- 0939-5555
- eISSN
- 1432-0584
- DOI
- 10.1007/s00277-004-0969-1
- pmid
- 15538567
- Publisher site
- See Article on Publisher Site
Abstract
Patterns of DNA methylation are substantially altered in malignancies compared to normal tissue, with both genome-wide hypomethylation and regional increase of cytosine methylation at dinucleotides of cytosine and guanine, i.<?A3B2 show $132#?>e., CpG dinucleotides. While genome-wide hypomethylation renders chromosomes instable, hypermethylation of CpGs in promoter regions is generally associated with transcriptional silencing, e.<?A3B2 show $132#?>g., of tumor suppressor genes. To investigate whether disease-specific methylation profiles exist for different entities of acute leukemia, a microarray-based DNA methylation analysis simultaneously assessing 249 CpG dinucleotides originating from 57 genes was employed. Hereby, samples from precursor B-cell acute lymphoblastic leukemia (ALL) could be distinguished from cases of acute myeloid leukemia by virtue of N33, EGR4, CDC2, CCND2, or MOS hypermethylation in ALL.
Journal
Annals of Hematology – Springer Journals
Published: Apr 1, 2005