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Directions of Migration of Bone Marrow Mononuclears after Intracoronary Transventricular Injection

Directions of Migration of Bone Marrow Mononuclears after Intracoronary Transventricular Injection Directions of migration of mononuclear bone marrow cells after intracoronary transventricular injection procedure developed by us were experimentally studied. After nonselective injection of cells into the right and left coronary arteries in rats, the labeled cells were detected only in the damaged zone of the myocardium. Localization of transplanted mononuclears in the scar attests to their homing into the damaged zone. Numerous cells were found in the red pulp of the spleen and solitary cells were detected in the liver and lungs. In the heart, the labeled transplanted cells were detected only in the scar zone at all terms of the study; they were not incorporated into the vascular walls, but were surrounded by thick bundles of collagen fibers and probably underwent differentiation into fibroblasts. No data on possible differentiation of the transplanted cells into vascular cells or cardiomyocytes were obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of Experimental Biology and Medicine Springer Journals

Directions of Migration of Bone Marrow Mononuclears after Intracoronary Transventricular Injection

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer Science+Business Media, Inc.
Subject
Biomedicine; Laboratory Medicine ; Pathology ; Cell Biology; Internal Medicine ; Biomedicine general
ISSN
0007-4888
eISSN
1573-8221
DOI
10.1007/s10517-010-0800-z
Publisher site
See Article on Publisher Site

Abstract

Directions of migration of mononuclear bone marrow cells after intracoronary transventricular injection procedure developed by us were experimentally studied. After nonselective injection of cells into the right and left coronary arteries in rats, the labeled cells were detected only in the damaged zone of the myocardium. Localization of transplanted mononuclears in the scar attests to their homing into the damaged zone. Numerous cells were found in the red pulp of the spleen and solitary cells were detected in the liver and lungs. In the heart, the labeled transplanted cells were detected only in the scar zone at all terms of the study; they were not incorporated into the vascular walls, but were surrounded by thick bundles of collagen fibers and probably underwent differentiation into fibroblasts. No data on possible differentiation of the transplanted cells into vascular cells or cardiomyocytes were obtained.

Journal

Bulletin of Experimental Biology and MedicineSpringer Journals

Published: Mar 26, 2010

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