Access the full text.
Sign up today, get DeepDyve free for 14 days.
KJ Osterziel, A Perrot (2005)
Dilated cardiomyopathy: more genes means more phenotypesEur Heart J, 26
DE Jaalouk, J Lammerding (2009)
Mechanotransduction gone awryNat Rev Mol Cell Biol, 10
M Pasotti, C Klersy, A Pilotto (2008)
Long-term outcome and risk stratification in dilated cardiolaminopathiesJ Am Coll Cardiol, 52
B Meder, J Haas, A Keller (2011)
Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathiesCirc Cardiovasc Genet, 4
SV Raman, EA Sparks, PM Baker (2007)
Mid-myocardial fibrosis by cardiac magnetic resonance in patients with lamin A/C cardiomyopathy: possible substrate for diastolic dysfunctionJ Cardiovasc Magn Reson, 9
P Charron, M Arad, E Arbustini (2010)
Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on myocardial and pericardial diseasesEur Heart J, 31
UC Hoppe, M Bohm, R Dietz (2005)
Guidelines for therapy of chronic heart failureZ Kardiol, 94
L Mestroni, B Maisch, WJ McKenna (1999)
Guidelines for the study of familial dilated cardiomyopathies. Collaborative Research Group of the European Human and Capital Mobility Project on Familial Dilated CardiomyopathyEur Heart J, 20
P Ehlermann, S Lehrke, T Papavassiliu (2011)
Sudden cardiac death in a patient with lamin A/C mutation in the absence of dilated cardiomyopathy or conduction diseaseClin Res Cardiol, 100
JA Towbin, NE Bowles (2002)
The failing heartNature, 415
W Grimm, M Christ, J Bach (2003)
Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy StudyCirculation, 108
EL Burkett, RE Hershberger (2005)
Clinical and genetic issues in familial dilated cardiomyopathyJ Am Coll Cardiol, 45
JP Tintelen, RM Hofstra, H Katerberg (2007)
High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinicsAm Heart J, 154
BJ Maron, JA Towbin, G Thiene (2006)
Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and PreventionCirculation, 113
C Meune, JH Berlo, F Anselme (2006)
Primary prevention of sudden death in patients with lamin A/C gene mutationsN Engl J Med, 354
I Kindermann, C Barth, F Mahfoud (2012)
Update on myocarditisJ Am Coll Cardiol, 59
DP Zipes, AJ Camm, M Borggrefe (2006)
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death – executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice GuidelinesEur Heart J, 27
A Kadish, A Dyer, JP Daubert (2004)
Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathyN Engl J Med, 350
I Kindermann, M Kindermann, R Kandolf (2008)
Predictors of outcome in patients with suspected myocarditisCirculation, 118
M Jessup, WT Abraham, DE Casey (2009)
2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines: developed in collaboration with the International Society for Heart and Lung TransplantationCirculation, 119
P Elliott, B Andersson, E Arbustini (2008)
Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on myocardial and pericardial diseasesEur Heart J, 29
D Fatkin (2011)
Guidelines for the diagnosis and management of familial dilated cardiomyopathyHeart Lung Circ, 20
W Jung, D Andresen, M Block (2006)
Guidelines for the implantation of defibrillatorsClin Res Cardiol, 95
JH Berlo, WG Voogt, AJ Kooi (2005)
Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death?J Mol Med, 83
LT Cooper, KL Baughman, AM Feldman (2007)
The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of CardiologyJ Am Coll Cardiol, 50
DP Leong, A Chakrabarty, N Shipp (2012)
Effects of myocardial fibrosis and ventricular dyssynchrony on response to therapy in new-presentation idiopathic dilated cardiomyopathy: insights from cardiovascular magnetic resonance and echocardiographyEur Heart J, 33
Die dilatative Kardiomyopathie (DCM) ist in 20–50 % der Fälle familiär gehäuft und somit genetisch bedingt. Derzeit ist eine Vielzahl von Mutationen in mehr als 40 Genen bekannt, die etwa 20 % aller familiären Fälle erklären. Die strukturierte Erhebung der Familienanamnese mit Erstellen eines Stammbaums ist obligater Bestandteil der Erstdiagnostik bei DCM. Über eine Familienuntersuchung zur Früherkennung können weitere Risikopersonen identifiziert werden. Mit Ausnahme des Lamin-A/C-Gens (LMNA) erlaubt die genetische Diagnostik bisher noch keine Risikostratifizierung. Eine DCM aufgrund einer LMNA-Mutation ist mit einem hohen Risiko für den plötzlichen Herztod verbunden. Bei familiären AV-Blockierungen, plötzlichem Herztod sowie einer begleitenden Muskelerkrankung sollte eine LMNA-Mutation ausgeschlossen werden. Eine ICD-Implantation ist unabhängig von der Ätiologie bei einer chronisch eingeschränkten LVEF unter 35 % indiziert, wobei dies mit Einschränkungen für symptomfreie Patienten im Stadium NYHA I gilt. Grundsätzlich sollte vor ICD-Implantation für 3–12 Monate eine optimierte medikamentöse Therapie durchgeführt werden.
Herzschrittmachertherapie + Elektrophysiologie – Springer Journals
Published: Sep 26, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.