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- Publisher
- Springer Journals
- Copyright
- Copyright © 2003 by Springer-Verlag
- Subject
- LifeSciences
- ISSN
- 0031-6768
- eISSN
- 1432-2013
- DOI
- 10.1007/s00424-003-1152-6
- pmid
- 12908109
- Publisher site
- See Article on Publisher Site
Abstract
Ubiquitination of proteins such as ion transporters appears to be an important process in the regulation of their membrane expression. Recently, using two-hybrid screening, we have selected a potential partner for the α-subunit of the amiloride-sensitive epithelial sodium channel (ENaC): the WWP1 protein, a ubiquitin ligase belonging to the Nedd4 family. To establish whether WWP1 is co-expressed with ENaC, we employed in situ hybridisation, immunohistochemistry and Western blotting to determine the expression of WWP1 in various tissues and cell lines, including those known to express ENaC. As expected, WWP1 was expressed, like ENaC, in the bronchiolar epithelium. However it was also present in the proximal colon and the proximal part of the nephron (where ENaC is not expressed) and absent in the distal parts of the nephron (where ENaC is expressed abundantly). These results suggest that other channels or transport proteins, containing specific domains, such as PY motifs, could be the targets for regulation by WWP1.
Journal
Pflügers Archiv European Journal of Physiologyl of Physiology – Springer Journals
Published: Aug 8, 2003