Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)

Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study... Objective: Catechins are bioactive flavonoids present in tea, fruits, and vegetables. Previous epidemiological studies regarding tea and cancer risk were inconclusive, possibly because catechins are also present in other plant foods. We investigated whether a high intake of catechins are associated with cancer incidence among postmenopausal women. Methods: A cohort of 34,651 postmenopausal cancer-free women aged 55–69 years were followed from 1986 to 1998. At baseline, data on diet, medical history, and lifestyle were collected. Incident cancers were obtained through linkage with a cancer registry. Cox proportional hazards analysis was used to estimate risk ratios. Results: After adjustment for potential confounders, catechin intake was inversely associated with rectal cancer incidence only (risk ratios from lowest to highest quartile: 1.00, 0.93, 0.73, and 0.55; p for trend 0.02). Non-significant inverse trends were found for cancer of the upper digestive tract, pancreas, and for hematopoietic cancers. Catechins derived primarily from fruits, (+)-catechin and (−)-epicatechin, tended to be inversely associated with upper digestive tract cancer, whereas catechins derived from tea were inversely associated with rectal cancer. Conclusions: Among several cancers studied, our data suggest that catechin intake may protect against rectal cancer. The distinct effects found for catechins derived from solid foods (fruits) and beverages (tea) may be due to differences in bioavailability or metabolism of the catechins, or to their interactions with other dietary components. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Causes & Control Springer Journals

Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)

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Publisher
Springer Journals
Copyright
Copyright © 2002 by Kluwer Academic Publishers
Subject
Biomedicine; Cancer Research; Biomedicine, general; Oncology; Public Health; Epidemiology; Hematology
ISSN
0957-5243
eISSN
1573-7225
DOI
10.1023/A:1015290131096
Publisher site
See Article on Publisher Site

Abstract

Objective: Catechins are bioactive flavonoids present in tea, fruits, and vegetables. Previous epidemiological studies regarding tea and cancer risk were inconclusive, possibly because catechins are also present in other plant foods. We investigated whether a high intake of catechins are associated with cancer incidence among postmenopausal women. Methods: A cohort of 34,651 postmenopausal cancer-free women aged 55–69 years were followed from 1986 to 1998. At baseline, data on diet, medical history, and lifestyle were collected. Incident cancers were obtained through linkage with a cancer registry. Cox proportional hazards analysis was used to estimate risk ratios. Results: After adjustment for potential confounders, catechin intake was inversely associated with rectal cancer incidence only (risk ratios from lowest to highest quartile: 1.00, 0.93, 0.73, and 0.55; p for trend 0.02). Non-significant inverse trends were found for cancer of the upper digestive tract, pancreas, and for hematopoietic cancers. Catechins derived primarily from fruits, (+)-catechin and (−)-epicatechin, tended to be inversely associated with upper digestive tract cancer, whereas catechins derived from tea were inversely associated with rectal cancer. Conclusions: Among several cancers studied, our data suggest that catechin intake may protect against rectal cancer. The distinct effects found for catechins derived from solid foods (fruits) and beverages (tea) may be due to differences in bioavailability or metabolism of the catechins, or to their interactions with other dietary components.

Journal

Cancer Causes & Control – Springer Journals

Published: Oct 10, 2004

References

  • WCRF/AICR, Food, Nutrition and the Prevention of Cancer: a global perspective
  • WCRF/AICR, Food, Nutrition and the Prevention of Cancer: a global perspective
  • The Flavonoids: Advances in Research since 1986
    Middleton, E; Kandaswami, C
  • The Flavonoids: Advances in Research since 1986
    Harborne, JB
  • Catechin intake and associated dietary and lifestyle factors in a representative sample of Dutch men and women
    Arts, ICW; Hollman, PCH; Feskens, EJM; de Mesquita, HB; Kromhout, D
  • Tea chemistry
    Harbowy, ME; Balentine, DA
  • Inhibition of carcinogenesis by tea: the evidence from experimental studies
    Dreosti, IE; Wargovich, MJ; Yang, CS
  • Tea in chemoprevention of cancer: epidemiologic and experimental studies (review)
    Katiyar, SK; Mukhtar, H
  • Green tea and cancer in humans: a review of the literature
    Bushman, JL
  • Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods
    Arts, ICW; Van de Putte, B; Hollman, PCH
  • Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk
    Arts, ICW; Van de Putte, B; Hollman, PCH
  • The use of a self-administered questionnaire to assess diet four years in the past
    Willett, WC; Sampson, L; Browne, ML
  • Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire
    Feskanich, D; Rimm, EB; Giovannucci, EL
  • Dietary assessment of older Iowa women with a food frequency questionnaire: nutrient intake, reproducibility, and comparison with 24-hour dietary recall interviews
    Munger, RG; Folsom, AR; Kushi, LH; Kaye, SA; Sellers, TA
  • Statistical Bulletin
    Putnam, JJ; Allshouse, JE
  • Dietary catechins and epithelial cancer incidence: the Zutphen elderly study
    Arts, ICW; Hollman, PCH; Bueno de Mesquita, HB; Feskens, EJM; Kromhout, D
  • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    Rice-Evans, CA; Miller, NJ; Paganga, G
  • Food, Nutrition and the Prevention of Cancer: a Global Perspective
  • A prospective cohort study on vegetable and fruit consumption and stomach cancer riskin the Netherlands
    Botterweck, AAM; Van den Brandt, PA; Goldbohm, RA
  • Blacktea consumption and cancer risk: a prospective study
    Heilbrun, LK; Nomura, A; Stemmermann, GN
  • Tea and coffee consumption and riskof colon and rectal cancer in middle-aged Finnish men
    Hartman, TJ; Tangrea, JA; Pietinen, P
  • Consumption of blacktea and cancer risk: a prospective cohort study
    Goldbohm, RA; Hertog, MGL; Brants, HA; Van Poppel, G; Van den Brandt, PA
  • Tea consumption and cancer
    Kinlen, LJ; Willows, AN; Goldblatt, P; Yudkin, J
  • Tea and coffee consumption and the riskof digestive tract cancers: data from a comparative case-referent study in Japan
    Inoue, M; Tajima, K; Hirose, K
  • Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3,530 cases and 7,057 controls
    Tavani, A; Pregnolato, A; LaVecchia, C; Negri, E; Talamini, R; Franceschi, S
  • Coffee, tea, tobacco, and cancer of the large bowel
    Baron, JA; Gerhardsson de Verdier, M; Ekbom, A
  • Tea consumption and cancer risk
    La Vecchia, C; Negri, E; Franceschi, S; D'Avanzo, B; Boyle, P
  • A case-control study of diet and colo-rectal cancer in northern Italy
    La Vecchia, C; Negri, E; Decarli, A
  • A comparative case-control study of colorectal cancer and adenoma
    Kato, I; Tominaga, S; Matsuura, A; Yoshii, Y; Shirai, M; Kobayashi, S
  • Cancer Epidemiology and Prevention
    Schottenfeld, D; Winawer, SJ
  • Colorectal cancer: molecules and populations
    Potter, JD
  • Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis?
    Konishi, K; Fujii, T; Boku, N
  • Robbins' Pathologic Basis of Disease
    Crawford, JM
  • Die Gehalte an Hydroxyzimtsa¨ ure-Verbindungen und Catechinen in Kern-und Steinobst [Contents of hydroxycinnamic acid derivatives and catechins in pome and stone fruit]
    Risch, B; Herrmann, K
  • Functional food science and defence against reactive oxidative species
    Diplock, AT; Charleux, JL; Crozier-Willi, G
  • Flavonols, flavones and flavanols-nature, occurrence and dietary burden
    Hollman, PCH; Arts, ICW
  • Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies
    Yang, CS; Lee, MJ; Chen, LS
  • Comparative study of the reversed-phase high-performance liquid chromatography of blacktea liquors with special reference to the thearubigins
    Bailey, RG; Nursten, HE; McDowell, I
  • Hippuric acid as a major excretion product associated with black tea consumption
    Clifford, MN; Copeland, EL; Bloxsidge, JP; Mitchell, LA
  • The chemistry of tea flavonoids
    Balentine, DA; Wiseman, SA; Bouwens, LCM

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