Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Development and initial testing of normal reference MR images for the brain at ages 65–70 and 75–80years

Development and initial testing of normal reference MR images for the brain at ages 65–70 and... Interpretation of brain images from older patients requires knowledge of changes that occur with healthy ageing. We constructed and tested a reference template for older subjects. We used MR images from normal subjects aged 65–70 and 75–80 to generate average age-specific images. We ranked the T2-weighted images by worsening brain tissue loss to create a diagram of key centiles. Two neuroradiologists tested the template during routine reporting; eight radiologists read 99 MR examinations without and then with the template. Fifty-four subjects (65–70 years) and 25 subjects (75–80 years) formed the reference images. For the two neuroradiologists, the reference template reduced the abnormal scan reporting from 28/42 without to 3/42 with the template. Of 99 MR examinations assessed by eight radiologists, 39/58 scans (67%) reported as moderate or severe atrophy without the template were reported as normal with the template (p = 0.00011). Reference templates of the brain at older ages can “calibrate” radiology reporting. They could also be useful for research into ageing and related conditions. Larger numbers of examinations from more diverse populations and at different ages are required to increase the versatility of these templates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Radiology Springer Journals

Development and initial testing of normal reference MR images for the brain at ages 65–70 and 75–80years

Download PDF
7 pages

Loading next page...
 
/lp/springer-journals/development-and-initial-testing-of-normal-reference-mr-images-for-the-rb0hZE0q3o

References (10)

Publisher
Springer Journals
Copyright
Copyright © 2008 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine ; Ultrasound; Neuroradiology ; Imaging / Radiology; Interventional Radiology ; Diagnostic Radiology
ISSN
0938-7994
eISSN
1432-1084
DOI
10.1007/s00330-008-1119-2
pmid
18690455
Publisher site
See Article on Publisher Site

Abstract

Interpretation of brain images from older patients requires knowledge of changes that occur with healthy ageing. We constructed and tested a reference template for older subjects. We used MR images from normal subjects aged 65–70 and 75–80 to generate average age-specific images. We ranked the T2-weighted images by worsening brain tissue loss to create a diagram of key centiles. Two neuroradiologists tested the template during routine reporting; eight radiologists read 99 MR examinations without and then with the template. Fifty-four subjects (65–70 years) and 25 subjects (75–80 years) formed the reference images. For the two neuroradiologists, the reference template reduced the abnormal scan reporting from 28/42 without to 3/42 with the template. Of 99 MR examinations assessed by eight radiologists, 39/58 scans (67%) reported as moderate or severe atrophy without the template were reported as normal with the template (p = 0.00011). Reference templates of the brain at older ages can “calibrate” radiology reporting. They could also be useful for research into ageing and related conditions. Larger numbers of examinations from more diverse populations and at different ages are required to increase the versatility of these templates.

Journal

European Radiology – Springer Journals

Published: Aug 9, 2008

There are no references for this article.