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Developing Neurobiological Endophenotypes that Reflect Failure to Control Alcohol Consumption and Dependence

Developing Neurobiological Endophenotypes that Reflect Failure to Control Alcohol Consumption and... Alcohol-use disorders (AUDs) are a major public health concern in the United States. To better understand the etiology of alcohol dependence and to identify physiological and behavioral markers that predict alcohol use progression, research has focused on linking diagnostic phenotypes with genetic variation. In recent years, neurobiological endophenotypes have largely surpassed clinical symptoms as the major phenotypes of interest, because they are typically more proximal to underlying genetic mechanisms, and can help to fill the gaps between genetic variation and clinical diagnosis. To date, numerous useful neurobiological endophenotypes for alcohol dependence have been uncovered, including those related to reward dysregulation, impulsivity, and subjective response to alcohol, In general, further work is needed to demonstrate direct associations between AUD endophenotypes and specific genetic variation. Future research would also benefit from applying a theoretical framework emphasizing the shifting imbalance between reward and control networks that occurs during the typical progression from recreational drinking to alcohol dependence. Identifying endophenotypes characteristic of different stages of addiction could have important diagnostic and treatment implications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Addiction Reports Springer Journals

Developing Neurobiological Endophenotypes that Reflect Failure to Control Alcohol Consumption and Dependence

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer International Publishing AG
Subject
Medicine & Public Health; Psychiatry; Neurology
eISSN
2196-2952
DOI
10.1007/s40429-013-0007-2
Publisher site
See Article on Publisher Site

Abstract

Alcohol-use disorders (AUDs) are a major public health concern in the United States. To better understand the etiology of alcohol dependence and to identify physiological and behavioral markers that predict alcohol use progression, research has focused on linking diagnostic phenotypes with genetic variation. In recent years, neurobiological endophenotypes have largely surpassed clinical symptoms as the major phenotypes of interest, because they are typically more proximal to underlying genetic mechanisms, and can help to fill the gaps between genetic variation and clinical diagnosis. To date, numerous useful neurobiological endophenotypes for alcohol dependence have been uncovered, including those related to reward dysregulation, impulsivity, and subjective response to alcohol, In general, further work is needed to demonstrate direct associations between AUD endophenotypes and specific genetic variation. Future research would also benefit from applying a theoretical framework emphasizing the shifting imbalance between reward and control networks that occurs during the typical progression from recreational drinking to alcohol dependence. Identifying endophenotypes characteristic of different stages of addiction could have important diagnostic and treatment implications.

Journal

Current Addiction ReportsSpringer Journals

Published: Jan 9, 2014

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