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Determining the Role of Gene Expression Assays in Local Therapy for Breast Cancer: First Steps with a Positive Impression

Determining the Role of Gene Expression Assays in Local Therapy for Breast Cancer: First Steps... Ann Surg Oncol (2015) 22:1057–1058 DOI 10.1245/s10434-014-4253-x ED ITORIA L – BREA S T O NCOLO G Y Determining the Role of Gene Expression Assays in Local Therapy for Breast Cancer: First Steps with a Positive Impression Mackenzie Daly, MD Department of Radiation Oncology, Washington University School of Medicine, St Louis Determining when post-mastectomy radiation therapy locoregional recurrence (LRR) and improvement in breast (PMRT) should be utilized in breast cancer patients with cancer mortality for this patient population. T1 or T2 tumors and 1–3 positive lymph nodes is an area of In the absence of clear, randomized data, oncologists are uncertainty. In this patient population, balancing the ben- forced to weigh clinicopathologic risk factors, ultimately efits of improved local control and overall survival with the relying on their clinical judgment to recommend or not long-term complications of therapeutic radiation relies recommend PMRT in patients with small primary tumors 1,2 heavily on the ‘art of medicine’. The paper submitted by (T1–T2) and 1–3 positive lymph nodes. While tallying up Dr. Jegadeesh and colleagues published in this issue of an individual patient’s risk factors for local recurrence, Annals of Surgical Oncology suggests that the 21-gene lymphovascular invasion, tumor size, nodal involvement, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgical Oncology Springer Journals

Determining the Role of Gene Expression Assays in Local Therapy for Breast Cancer: First Steps with a Positive Impression

Daly, Mackenzie
Annals of Surgical Oncology , Volume 22 (4) – Dec 2, 2014
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References (16)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Society of Surgical Oncology
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
1068-9265
eISSN
1534-4681
DOI
10.1245/s10434-014-4253-x
pmid
25448801
Publisher site
See Article on Publisher Site

Abstract

Ann Surg Oncol (2015) 22:1057–1058 DOI 10.1245/s10434-014-4253-x ED ITORIA L – BREA S T O NCOLO G Y Determining the Role of Gene Expression Assays in Local Therapy for Breast Cancer: First Steps with a Positive Impression Mackenzie Daly, MD Department of Radiation Oncology, Washington University School of Medicine, St Louis Determining when post-mastectomy radiation therapy locoregional recurrence (LRR) and improvement in breast (PMRT) should be utilized in breast cancer patients with cancer mortality for this patient population. T1 or T2 tumors and 1–3 positive lymph nodes is an area of In the absence of clear, randomized data, oncologists are uncertainty. In this patient population, balancing the ben- forced to weigh clinicopathologic risk factors, ultimately efits of improved local control and overall survival with the relying on their clinical judgment to recommend or not long-term complications of therapeutic radiation relies recommend PMRT in patients with small primary tumors 1,2 heavily on the ‘art of medicine’. The paper submitted by (T1–T2) and 1–3 positive lymph nodes. While tallying up Dr. Jegadeesh and colleagues published in this issue of an individual patient’s risk factors for local recurrence, Annals of Surgical Oncology suggests that the 21-gene lymphovascular invasion, tumor size, nodal involvement,

Journal

Annals of Surgical Oncology – Springer Journals

Published: Dec 2, 2014

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