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References (4)
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M. Schulman, D. Valentino, M. Nallin, L. Kaplan (1986)
Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectinsAntimicrobial Agents and Chemotherapy, 29
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Ying-Xin Zhang, C. Denoya, D. Skinner, R. Fedechko, H. McArthur, Margaret Morgenstern, Richard Davies, Sandra Lobo, Kevin Reynolds, C. Hutchinson (1999)
Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.Microbiology, 145 ( Pt 9)
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Haruo Ikeda, T. Nonomiya, Satoshi Ōmura (2001)
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthasesJournal of Industrial Microbiology and Biotechnology, 27
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V. Mironov, A. Sergeeva, A. Gavrilina, V. Danilenko (2003)
[Dependence of the composition of the avermectin complex of Streptomyces avermitilis on glucose content of the growth medium].Prikladnaia biokhimiia i mikrobiologiia, 39 2
- Publisher
- Springer Journals
- Copyright
- Copyright © 2003 by MAIK “Nauka/Interperiodica”
- Subject
- Life Sciences; Medical Microbiology; Biochemistry, general; Microbiology
- ISSN
- 0003-6838
- eISSN
- 1608-3024
- DOI
- 10.1023/A:1022594114690
- Publisher site
- See Article on Publisher Site
Abstract
The effects of the glucose concentration in the medium and O-methyl-L-threonine resistance on the ratio of components of the avermectin complex produced by Streptomyces avermitilishave been studied. Glucose deficiency increases the ratio of components A and ain the complex, while decreasing that of components 1. A mutation that renders the microorganisms resistant to O-methyl-L-threonine (an analogue of isoleucine) increases the ratio of components a in the complex, while decreasing that of components 1. The distribution of aand b in fractions 1and 2 remains constant: the values of the ratio a/b in the fractions amount, respectively, to 1 : 1 and 2 : 1. The relation of the variations in the composition of the avermectin complex to changes in the carbohydrate metabolism of the producer stain, underlain by availability of the source of carbon, is discussed.
Journal
Applied Biochemistry and Microbiology – Springer Journals
Published: Oct 17, 2004