Reactions 1704, p130 - 2 Jun 2018 Blurred vision, nausea and peripheral oedema: case report A 51-year-old woman developed occasional nausea, peripheral oedema and blurred vision following treatment with dabrafenib and trametinib [time to reactions onsets not stated]. The woman, who was diagnosed with an anaplastic ganglioglioma (WHO grade III), underwent surgery and began adjuvant radiotherapy. However, 8 days following surgery, a repeat MRI study of her brain and spine revealed tumour progression with extensive leptomeningeal disease. Later, she was considered for combination therapy of radiation with BRAF and MEK inhibitors, dabrafenib and trametinib, respectively. She received eight 30 day cycles of oral dabrafenib 150mg twice daily and oral trametinib 2mg daily. She developed mild side-effects during the treatment. She reported occasional nausea, which was adequately controlled with ondansetron. She also developed peripheral oedema in the arms and legs as well as blurred vision, which improved over the time period. Three months following therapy, MRI demonstrated a marked reduction in the tumour burden, which was stable at 6 months. Also, she showed significant improvement in her functional status. Author comment: "The therapy was overall well-tolerated, with mild and expected side effects. She complained of occasional nausea, which was adequately controlled with Ondansetron. She also described some peripheral edema in the arms and legs as well as blurred vision, which improved over time." Beland B, et al. Unprecedented response to combination BRAF and MEK inhibitors in adult anaplastic ganglioglioma. Journal of Neuro-Oncology 137: 667-669, No. 3, May 2018. Available from: URL: http://doi.org/10.1007/ s11060-018-2760-5 - Canada 803323916 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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