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Cytotoxic phenolic constituents of Acer tegmentosum maxim

Cytotoxic phenolic constituents of Acer tegmentosum maxim The chromatographic separation of the MeOH extract from the twigs of Acer tegmentosum led to the isolation of ten phenolic compounds. The structures of these compounds were determined using spectroscopic methods as 3,7,3′,4′-tetramethyl-quercetin ( 1 ), 5,3′-dihydroxy-3,7,4′-trimethoxy flavone ( 2 ), 2,6-dimethoxy- p -hydroquinone ( 3 ), (-)-catechin ( 4 ), morin-3-O-α-L-lyxoside ( 5 ), p -hydroxy phenylethyl-O-ß-D-glucopyranoside ( 6 ), 3,5-dimethoxy-4-hydroxy phenyl-1- O -ß-D-glucoside ( 7 ), fraxin, ( 8 ), 3,5-dimethoxy-benzyl alcohol 4- O -ß-D-glucopyrano-side ( 9 ) and 4-(2,3-dihydroxy propyl)-2,6-dimethoxy phenyl ß-D-glucopyranoside ( 10 ). The compounds were examined for their cytotoxic activity against five cancer cell lines. Compound 3 exhibited good cytotoxic activity against five human cancer cell lines with ED 50 values ranging from 1.32 to 3.85 μM. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pharmacal Research Springer Journals

Cytotoxic phenolic constituents of Acer tegmentosum maxim

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References (19)

Publisher
Springer Journals
Copyright
Copyright © 2006 by The Pharmaceutical Society of Korea
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology
ISSN
0253-6269
eISSN
1976-3786
DOI
10.1007/BF02969296
Publisher site
See Article on Publisher Site

Abstract

The chromatographic separation of the MeOH extract from the twigs of Acer tegmentosum led to the isolation of ten phenolic compounds. The structures of these compounds were determined using spectroscopic methods as 3,7,3′,4′-tetramethyl-quercetin ( 1 ), 5,3′-dihydroxy-3,7,4′-trimethoxy flavone ( 2 ), 2,6-dimethoxy- p -hydroquinone ( 3 ), (-)-catechin ( 4 ), morin-3-O-α-L-lyxoside ( 5 ), p -hydroxy phenylethyl-O-ß-D-glucopyranoside ( 6 ), 3,5-dimethoxy-4-hydroxy phenyl-1- O -ß-D-glucoside ( 7 ), fraxin, ( 8 ), 3,5-dimethoxy-benzyl alcohol 4- O -ß-D-glucopyrano-side ( 9 ) and 4-(2,3-dihydroxy propyl)-2,6-dimethoxy phenyl ß-D-glucopyranoside ( 10 ). The compounds were examined for their cytotoxic activity against five cancer cell lines. Compound 3 exhibited good cytotoxic activity against five human cancer cell lines with ED 50 values ranging from 1.32 to 3.85 μM.

Journal

Archives of Pharmacal Research – Springer Journals

Published: Dec 1, 2006

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