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Cytotoxic metabolites of Streptimonospora salina

Cytotoxic metabolites of Streptimonospora salina Streptimonospora salina gen. nov., sp. nov. was found to produce three phenoxazinone antibiotics, 2-amino-3H-phenoxazin-3-one (1), 2-methylamino-3H-phenoxazin-3-one (2), 2-acetylamino-3H-phenoxazin-3-one (3), and one phenazine antibiotic, phenazine-1-carboxylic acid (4). The chemical structures of the compounds were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). Compounds 1-4 exhibited modest cytotoxicity against a human renal carcinoma cell line ACHN with IC50 values of 35.4, 12.4, 65.4, and 82.9 μM, respectively. Compound 2 was discovered for the first time from a biological origin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Natural Compounds Springer Journals

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer Science+Business Media, Inc.
Subject
Pharmacy; Plant Sciences ; Organic Chemistry; Pharmacy
ISSN
0009-3130
eISSN
1573-8388
DOI
10.1007/s10600-008-9102-3
Publisher site
See Article on Publisher Site

Abstract

Streptimonospora salina gen. nov., sp. nov. was found to produce three phenoxazinone antibiotics, 2-amino-3H-phenoxazin-3-one (1), 2-methylamino-3H-phenoxazin-3-one (2), 2-acetylamino-3H-phenoxazin-3-one (3), and one phenazine antibiotic, phenazine-1-carboxylic acid (4). The chemical structures of the compounds were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). Compounds 1-4 exhibited modest cytotoxicity against a human renal carcinoma cell line ACHN with IC50 values of 35.4, 12.4, 65.4, and 82.9 μM, respectively. Compound 2 was discovered for the first time from a biological origin.

Journal

Chemistry of Natural CompoundsSpringer Journals

Published: Oct 30, 2008

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