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Cytotoxic activities of various fractions extracted from some pharmaceutical insect relatives

Cytotoxic activities of various fractions extracted from some pharmaceutical insect relatives This research was performed to screen the cytotoxic activities of some pharmaceutical insect relatives. Cytotoxic activities of total extract and fractions of hexane, ethyl acetate, methanol, water and boiling water were extracted from four pharmaceutical insect relatives: the Chinese gall, the cicada slough, the hornet nest and the batryticated silkworm. These extracts were investigated against the cancer cell lines of L1210, P388 and SNU-1 in vitro tests. Results showed that, ED 50 against the cancer cell lines of L1210, P388 and SNU-1 were 0.55, 0.50, and 0.83 μg/ml in the ethyl acetate fraction from the Chinese gall; 1.07, 2.19, and 2.24 μg/ml in the ethyl acetate fraction, 1.51, 1.26, and 1.45 μg/ml in the water fraction and 1.48, 2.29, and 1.29 μg/ml in the boiling water fraction from the cicada slough; 3.31, 2.00, and 6.61 μg/ml in the water fraction from the hornet nest and 13.80, 19.95, and 31.62 μg/ml in the hexane fraction and 33.88, 21.88, and 25.12 μg/ml in the ethyl acetate fraction from the batryticated silkworm, respectively. All of the fractions metioned above showed high cytotoxic activities and could be suggested for further studies in vivo tests. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pharmacal Research Springer Journals

Cytotoxic activities of various fractions extracted from some pharmaceutical insect relatives

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References (9)

Publisher
Springer Journals
Copyright
Copyright © 1997 by The Pharmaceutical Society of Korea
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology
ISSN
0253-6269
eISSN
1976-3786
DOI
10.1007/BF02973996
pmid
18975187
Publisher site
See Article on Publisher Site

Abstract

This research was performed to screen the cytotoxic activities of some pharmaceutical insect relatives. Cytotoxic activities of total extract and fractions of hexane, ethyl acetate, methanol, water and boiling water were extracted from four pharmaceutical insect relatives: the Chinese gall, the cicada slough, the hornet nest and the batryticated silkworm. These extracts were investigated against the cancer cell lines of L1210, P388 and SNU-1 in vitro tests. Results showed that, ED 50 against the cancer cell lines of L1210, P388 and SNU-1 were 0.55, 0.50, and 0.83 μg/ml in the ethyl acetate fraction from the Chinese gall; 1.07, 2.19, and 2.24 μg/ml in the ethyl acetate fraction, 1.51, 1.26, and 1.45 μg/ml in the water fraction and 1.48, 2.29, and 1.29 μg/ml in the boiling water fraction from the cicada slough; 3.31, 2.00, and 6.61 μg/ml in the water fraction from the hornet nest and 13.80, 19.95, and 31.62 μg/ml in the hexane fraction and 33.88, 21.88, and 25.12 μg/ml in the ethyl acetate fraction from the batryticated silkworm, respectively. All of the fractions metioned above showed high cytotoxic activities and could be suggested for further studies in vivo tests.

Journal

Archives of Pharmacal Research – Springer Journals

Published: Apr 1, 1997

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