Corticosteroids in the brain

Corticosteroids in the brain The rat adrenal hormone corticosterone reaches the brain and binds to intracellular receptors. These receptors comprise high-affinity mineralocorticoid and lower-affinity glucocorticoid receptors that, upon activation, affect the transcription rate of specific genes. The two receptor types are discretely localized in the brain, with particularly high expression levels in the hippocampus. Here we review recent studies showing that electrical properties and structural aspects of hippocampal principal neurons are specifically regulated by mineralocorticoid- or glucocorticoid-receptor activation. The molecular mechanisms by which these cellular effects could be accomplished are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Neurobiology Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 1998 by Humana Press Inc
Subject
Life Sciences; Neurobiology; Neurology; Cell Biology
ISSN
0893-7648
eISSN
1559-1182
DOI
10.1007/BF02802026
pmid
9887448
Publisher site
See Article on Publisher Site

Abstract

The rat adrenal hormone corticosterone reaches the brain and binds to intracellular receptors. These receptors comprise high-affinity mineralocorticoid and lower-affinity glucocorticoid receptors that, upon activation, affect the transcription rate of specific genes. The two receptor types are discretely localized in the brain, with particularly high expression levels in the hippocampus. Here we review recent studies showing that electrical properties and structural aspects of hippocampal principal neurons are specifically regulated by mineralocorticoid- or glucocorticoid-receptor activation. The molecular mechanisms by which these cellular effects could be accomplished are discussed.

Journal

Molecular NeurobiologySpringer Journals

Published: Dec 29, 2007

References

  • Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro
    Andrade, R.; Nicoll, R. A.
  • Identification of a splice variant of the rat and human mineralocorticoid receptor genes
    Bloem, L.J.; Guo, C.; Pratt, J. H.

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