H N NC O O or Cu (OAC) .H O (15mol%) 2 2 + NC CN or + H N Solvent free, 80°C O NC H N O NH NH .H O 2 2 2 + O Ar Cu(OAC) .H O (20 mol %) 2 2 CN CN Solvent free, 80 °C NH Ar CHO + O CN & Malek Taher Maghsoodlou firstname.lastname@example.org; email@example.com Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran Faculty of Science, Velayat University, Iranshahr, Iran 123 7842 F. Mohamadpour et al. Keywords Copper(II) acetate monohydrate Spiro-4H-pyran derivatives 1H- pyrazolo[1,2-b]phthalazine-5,10-dione derivatives Solvent-free conditions Introduction Nowadays, most research has been focused on the study of synthesising heterocyclic compounds. Organic compounds containing nitrogen heterocyclic rings are important compounds in medicinal chemistry. The synthesis of biologically active spiropyran derivatives (spirooxindole) and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione deriva- tives have been given much attention because of their advantages in various biological (Figs. 1, 2) and pharmaceutical ﬁelds, for example, as anti-HIV , anti-tubercular , fungicidal , anticonvulsant  and anticancer [5, 6] agents; in addition, these spirocycles are MDM2 inhibitors  and progesterone receptor modulators . In recent decades, a number of
Research on Chemical Intermediates – Springer Journals
Published: Jun 30, 2016
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