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Conventional and non-conventional pathologic workup of specimens with early breast carcinomas

Conventional and non-conventional pathologic workup of specimens with early breast carcinomas The radiological – surgical parameters (tumour size, lesion distribution, disease extent and surgical margins) and the oncological morphologic parameters (tumour type and grade, hormone receptor status, proliferative activity and TNM stage) are equally important for adequate characterisation of early breast carcinomas. Conventional histopathology methods may be sufficient in determining oncological parameters while large-format histopathology used in context of systematic radiological – pathological correlation is the only adequate approach in determining the radiological – surgical parameters in modern breast pathology. This is particularly valid for the parameters of lesion distribution and disease extent, which prognostic power has recently been evidenced and which are often underestimated if conventional histology methods are used. This review will focus on the radiological – surgical parameters in early breast carcinomas, their clinical significance and the optimal methods of their assessment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png memo - Magazine of European Medical Oncology Springer Journals

Conventional and non-conventional pathologic workup of specimens with early breast carcinomas

Tot, T.
memo - Magazine of European Medical Oncology , Volume 4 (3) – Oct 13, 2011
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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Medicine & Public Health; Medicine/Public Health, general; Oncology
ISSN
1865-5041
eISSN
1865-5076
DOI
10.1007/s12254-011-0288-x
Publisher site
See Article on Publisher Site

Abstract

The radiological – surgical parameters (tumour size, lesion distribution, disease extent and surgical margins) and the oncological morphologic parameters (tumour type and grade, hormone receptor status, proliferative activity and TNM stage) are equally important for adequate characterisation of early breast carcinomas. Conventional histopathology methods may be sufficient in determining oncological parameters while large-format histopathology used in context of systematic radiological – pathological correlation is the only adequate approach in determining the radiological – surgical parameters in modern breast pathology. This is particularly valid for the parameters of lesion distribution and disease extent, which prognostic power has recently been evidenced and which are often underestimated if conventional histology methods are used. This review will focus on the radiological – surgical parameters in early breast carcinomas, their clinical significance and the optimal methods of their assessment.

Journal

memo - Magazine of European Medical Oncology – Springer Journals

Published: Oct 13, 2011

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