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Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
- Publisher
- Springer Journals
- Copyright
- Copyright © Akadémiai Kiadó 2020
- ISSN
- 2062-249X
- eISSN
- 2063-0212
- DOI
- 10.1007/s41981-019-00049-6
- Publisher site
- See Article on Publisher Site
Abstract
Under continuous processing conditions, C-N bond formation via SN2 and SNAr substitutions by amines can be an effective preparative method, especially when volatile amines are used under high pressure and temperature. We have demonstrated SN2 substitution of a 2° mesylate with ammonia and opening of an epoxide with benzylamine, and SNAr substitution of a heteroaryl chloride with aqueous ammonia on multi-kg scales. The homogeneous continuous processes offered better process control, higher efficiency, and comparable or superior reaction profiles and yields to batch conditions.Graphical abstractContinuous flow aminolysis under high temperature and pressure[graphic not available: see fulltext]
Journal
Journal of Flow Chemistry – Springer Journals
Published: Mar 5, 2020