Components of astrocytic intercellular calcium signaling

Components of astrocytic intercellular calcium signaling It has become evident that astrocytes play major roles in central nervous system (CNS) function. Because they are endowed with ion channels, transport pathways, and enzymatic intermediates optimized for ionic uptake, degradation of metabolic products, and inactivation of numerous substances, they are able to sense and correct for changes in neural microenvironment. Besides this housekeeping role, astrocytes modulate neuronal activity either by direct communication through gap junctions or through the release of neurotransmitters and/or nucleotides affecting nearby receptors. One prominent mode by which astrocytes regulate their own activity and influence neuronal behavior is via Ca2+ signals, which may be restricted within one cell or be transmitted throughout the interconnected syncytium through the propagation of intercellular calcium waves. This review aims to outline the most recent advances regarding the active communication of astrocytes that is encoded by intracellular calcium variation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Neurobiology Springer Journals

Components of astrocytic intercellular calcium signaling

Molecular Neurobiology, Volume 22 (3) – May 31, 2007

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Publisher
Springer Journals
Copyright
Copyright © 2001 by Humana Press Inc
Subject
Life Sciences; Neurobiology; Neurology; Cell Biology
ISSN
0893-7648
eISSN
1559-1182
DOI
10.1385/MN:22:1-3:167
pmid
11414278
Publisher site
See Article on Publisher Site

Abstract

It has become evident that astrocytes play major roles in central nervous system (CNS) function. Because they are endowed with ion channels, transport pathways, and enzymatic intermediates optimized for ionic uptake, degradation of metabolic products, and inactivation of numerous substances, they are able to sense and correct for changes in neural microenvironment. Besides this housekeeping role, astrocytes modulate neuronal activity either by direct communication through gap junctions or through the release of neurotransmitters and/or nucleotides affecting nearby receptors. One prominent mode by which astrocytes regulate their own activity and influence neuronal behavior is via Ca2+ signals, which may be restricted within one cell or be transmitted throughout the interconnected syncytium through the propagation of intercellular calcium waves. This review aims to outline the most recent advances regarding the active communication of astrocytes that is encoded by intracellular calcium variation.

Journal

Molecular NeurobiologySpringer Journals

Published: May 31, 2007

References

  • Spiral intercellular calcium waves in hippocampal slice cultures
    Harris-White, M. E.; Zanotti, A. S.; Frautschy, A. S.; Charles, A. C.
  • Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons
    Araque, A.; Parpura, V.; Sanzgiri, R. P.; Haydon, P. G.
  • Perspectives on spreading depression
    Martins-Ferreira, H.; Nedergaard, M.; Nicholson, C.
  • Glial calcium: homeostasis and signaling function
    Verkhratsky, A.; Orkand, R. K.; Kettenmann, H.
  • Glutamate-induced calcium signaling in astrocytes
    Kim, W. T.; Rioult, M. G.; Cornell-Bell, A. H.
  • Intercellular Ca2+ waves induce temporally and spatially distinct intracellular Ca2+ oscillations in glia
    Strahonja-Packard, A.; Sanderson, M. J.
  • Glutamate-mediated astrocyte-neuron signaling
    Parpura, V.; Basarsky, T. A.; Liu, F.; Jeftinija, S.; Haydon, P. G.
  • Dynamic imaging of purified individual synaptic vesicles
    Parpura, V.; Doyle, R. T.; Basarsky, T. A.; Henderson, E.; Haydon, P. G.

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