Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions

Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions 221 78 78 1 1 V. J. Brown S. B. Dunnett Department of Experimental Psychology University of Cambridge Downing Street CB2 3EB Cambridge UK Summary Separate groups of rats with unilateral 6-OHDA lesions of the nigrostriatal pathway received intrastriatal foetal (E14) substantia nigra suspension grafts, intrastriatal postnatal (P22–25) adrenal medulla suspension grafts using either collagenaseor trypsin-based dissociation procedures, intraventricular adrenal medulla grafts, or remained with lesions alone. Rats with nigral or adrenal suspension grafts, but not rats with adrenal solid grafts, showed reduced apomorphine-induced rotation in comparison with lesion rats. The nigral graft group alone showed substantial reduction of amphetamine-induced rotation, and this was the only group manifesting good long-term graft survival. These results indicate that nigral and adrenal grafts do not have comparable mechanisms of functional action, and suggest that adrenal grafts can ameliorate apomorphine-induced rotation by a non-specific mechanism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions

Experimental Brain Research, Volume 78 (1) – Nov 1, 1989

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Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
D.O.I.
10.1007/BF00230701
Publisher site
See Article on Publisher Site

Abstract

221 78 78 1 1 V. J. Brown S. B. Dunnett Department of Experimental Psychology University of Cambridge Downing Street CB2 3EB Cambridge UK Summary Separate groups of rats with unilateral 6-OHDA lesions of the nigrostriatal pathway received intrastriatal foetal (E14) substantia nigra suspension grafts, intrastriatal postnatal (P22–25) adrenal medulla suspension grafts using either collagenaseor trypsin-based dissociation procedures, intraventricular adrenal medulla grafts, or remained with lesions alone. Rats with nigral or adrenal suspension grafts, but not rats with adrenal solid grafts, showed reduced apomorphine-induced rotation in comparison with lesion rats. The nigral graft group alone showed substantial reduction of amphetamine-induced rotation, and this was the only group manifesting good long-term graft survival. These results indicate that nigral and adrenal grafts do not have comparable mechanisms of functional action, and suggest that adrenal grafts can ameliorate apomorphine-induced rotation by a non-specific mechanism.

Journal

Experimental Brain ResearchSpringer Journals

Published: Nov 1, 1989

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