Pharmaceutical Chem&try Journal Vol. 34, No. 4, 2000 COMPARATIVE EXPERIMENTAL INVESTIGATION OF THE ANABOLIC ACTIVITY OF PHYTOECDYSTEROIDS AND STERANABOLS V. N. Syrov 1 Translated from Khimiko-Farmatsevticheskii Zhumal, Vol. 34, No. 4, pp. 31 - 34, April, 2000. Original article submitted March 30, 1999. Many compounds originally isolated from plants have praemixta M. Pop. ; and turkesterone, from Ajuga been used since ancient times as drugs. Among the classes of turkestanika (Rgl.)Brig. . Ecdysterone triacetate and natural substances isolated relatively recently, of special in- tetraacetate were obtained by partial synthesis from ec- terest are the so-called phytoecdysteroids. These compounds, dysterone; 2-deoxy-a-ecdysone-22-0-acetate was synthe- structurally close or identical to the hormones of ecdysis sized proceeding from 2-deoxy-c~-ecdysone; turkesterone tri- (molting) and metamorphosis in insects, were found to be capable of activating pro- tein biosynthesis in of mammals . How- RSO OR 6 R 3 OR 4 ever, these drugs were not studied with re- ,%,, spect to their possible anabolizing action upon the organism, especially in compari- son with the steroidal anabolic prepara- R 1 tions- derivatives of the male sex hor- oH R30~ 0U mones, presently the most effective stimu- R2o lants of the protein-anabolic processes. R~O H O In
Pharmaceutical Chemistry Journal – Springer Journals
Published: Oct 24, 2006
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