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Erica Peters, R. Schwartz, Shuai Wang, K. O’grady, C. Blanco (2014)
Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence.Drug and alcohol dependence, 134
J. Jansma, H. Hell, L. Vanderschuren, M. Bossong, M. Bossong, Gerry Jager, Gerry Jager, René Kahn, Nick Ramsey (2013)
THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addictionTranslational Psychiatry, 3
Natania Crane, S. Langenecker, R. Mermelstein (2015)
Gender differences in the associations among marijuana use, cigarette use, and symptoms of depression during adolescence and young adulthood.Addictive behaviors, 49
G. Patton, C. Coffey, J. Carlin, S. Sawyer, M. Lynskey (2005)
Reverse gateways? Frequent cannabis use as a predictor of tobacco initiation and nicotine dependence.Addiction, 100 10
R. Dahl (2004)
Adolescent Brain Development: A Period of Vulnerabilities and Opportunities. Keynote AddressAnnals of the New York Academy of Sciences, 1021
S. Barrett, C. Darredeau, R. Pihl (2006)
Patterns of simultaneous polysubstance use in drug using university studentsHuman Psychopharmacology: Clinical and Experimental, 21
A. Castañé, E. Valjent, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde (2002)
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinenceNeuropharmacology, 43
H. Karoly, A. Bryan, B. Weiland, A. Mayer, A. Dodd, S. Ewing (2015)
Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescentsDevelopmental Cognitive Neuroscience, 16
M. Oscar-Berman, K. Marinković (2007)
Alcohol: Effects on Neurobehavioral Functions and the BrainNeuropsychology Review, 17
R. Mechoulam, L. Parker (2013)
The endocannabinoid system and the brain.Annual review of psychology, 64
C. Leroy, L. Karila, J. Martinot, M. Lukasiewicz, E. Duchesnay, C. Comtat, F. Dollé, A. Benyamina, E. Artiges, M. Ribeiro, M. Reynaud, C. Trichard (2012)
Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high‐resolution PET studyAddiction Biology, 17
M. Rocchetti, A. Crescini, S. Borgwardt, E. Caverzasi, P. Politi, Z. Atakan, P. Fusar-Poli (2013)
Is cannabis neurotoxic for the healthy brain? A meta‐analytical review of structural brain alterations in non‐psychotic usersPsychiatry and Clinical Neurosciences, 67
Danielle Ramo, Howard Liu, J. Prochaska (2012)
Tobacco and marijuana use among adolescents and young adults: a systematic review of their co-use.Clinical psychology review, 32 2
S. Heishman, Bethea Kleykamp, E. Singleton (2010)
Meta-analysis of the acute effects of nicotine and smoking on human performancePsychopharmacology, 210
S. Gage, Matthew Hickman, J. Heron, M. Munafo, G. Lewis, J. Macleod, S. Zammit (2014)
Associations of cannabis and cigarette use with psychotic experiences at age 18: findings from the Avon Longitudinal Study of Parents and ChildrenPsychological Medicine, 44
J. Sneider, S. Gruber, J. Rogowska, M. Silveri, D. Yurgelun-Todd (2012)
A Preliminary Study of Functional Brain Activation among Marijuana Users during Performance of a Virtual Water Maze TaskJournal of Addiction, 2013
R. Crean, Natania Crane, B. Mason (2011)
An Evidence-Based Review of Acute and Long-Term Effects of Cannabis Use on Executive Cognitive FunctionsJournal of Addiction Medicine, 5
E. Gardner (2011)
Addiction and brain reward and antireward pathways.Advances in psychosomatic medicine, 30
E. Dubé, J. O'Loughlin, I. Karp, D. Jutras-Aswad (2015)
Cigarette smoking may modify the association between cannabis use and adiposity in malesPharmacology Biochemistry and Behavior, 135
M. Scherma, P. Fadda, B. Foll, B. Forget, W. Fratta, S. Goldberg, G. Tanda (2008)
The endocannabinoid system: a new molecular target for the treatment of tobacco addiction.CNS & neurological disorders drug targets, 7 5
Gillian Schauer, C. Berg, M. Kegler, D. Donovan, M. Windle (2015)
Assessing the overlap between tobacco and marijuana: Trends in patterns of co-use of tobacco and marijuana in adults from 2003-2012.Addictive behaviors, 49
A. Batalla, S. Bhattacharyya, M. Yücel, P. Fusar-Poli, J. Crippa, S. Nogué, M. Torrens, J. Pujol, M. Farré, R. Martín-Santos (2013)
Structural and Functional Imaging Studies in Chronic Cannabis Users: A Systematic Review of Adolescent and Adult FindingsPLoS ONE, 8
K. Mackie (2008)
Cannabinoid Receptors: Where They are and What They doJournal of Neuroendocrinology, 20
J. Becker, M. Schaub, G. Gmel, S. Haug (2015)
Cannabis use and other predictors of the onset of daily cigarette use in young men: what matters most? Results from a longitudinal studyBMC Public Health, 15
A. Agrawal, M. Lynskey (2009)
Tobacco and cannabis co-occurrence: does route of administration matter?Drug and alcohol dependence, 99 1-3
A. Agrawal, J. Silberg, M. Lynskey, H. Maes, L. Eaves (2010)
Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins.Drug and alcohol dependence, 108 1-2
A. Jasinska, T. Zorick, A. Brody, E. Stein (2014)
Dual role of nicotine in addiction and cognition: A review of neuroimaging studies in humansNeuropharmacology, 84
J. Churchwell, M. Lopez-Larson, D. Yurgelun-Todd (2010)
Altered Frontal Cortical Volume and Decision Making in Adolescent Cannabis UsersFrontiers in Psychology, 1
J. Despres (2007)
The endocannabinoid system: a new target for the regulation of energy balance and metabolism.Critical pathways in cardiology, 6 2
K. Brady, R. Sinha (2005)
Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress.The American journal of psychiatry, 162 8
D. Kandel, E. Kandel (2015)
The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectivesActa Paediatrica, 104
R. Wetherill, K. Jagannathan, Nathan Hager, A. Childress, H. Rao, T. Franklin (2015)
Cannabis, Cigarettes, and Their Co-Occurring Use: Disentangling Differences in Gray Matter VolumeInternational Journal of Neuropsychopharmacology, 18
L. Jacobsen, K. Pugh, K. Pugh, R. Constable, M. Westerveld, W. Mencl (2007)
Functional Correlates of Verbal Memory Deficits Emerging During Nicotine Withdrawal in Abstinent Adolescent Cannabis UsersBiological Psychiatry, 61
L. Panlilio, C. Zanettini, Chanel Barnes, M. Solinas, S. Goldberg (2013)
Prior Exposure to THC Increases the Addictive Effects of Nicotine in RatsNeuropsychopharmacology, 38
A. Agrawal, A. Budney, M. Lynskey (2012)
The co-occurring use and misuse of cannabis and tobacco: a review.Addiction, 107 7
C. Akré, P. Michaud, A. Berchtold, J. Suris (2010)
Cannabis and tobacco use: where are the boundaries? A qualitative study on cannabis consumption modes among adolescents.Health education research, 25 1
S. González, M. Cascio, J. Fernández-Ruiz, F. Fezza, V. Marzo, J. Ramos (2002)
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaineBrain Research, 954
Rachel Rabin, T. George (2015)
A review of co-morbid tobacco and cannabis use disorders: possible mechanisms to explain high rates of co-use.The American journal on addictions, 24 2
E. Valjent, Jennifer Mitchell, M. Besson, J. Caboche, R. Maldonado (2002)
Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotineBritish Journal of Pharmacology, 135
R. Wetherill, Zhuo Fang, K. Jagannathan, A. Childress, H. Rao, T. Franklin (2015)
Cannabis, cigarettes, and their co-occurring use: Disentangling differences in default mode network functional connectivity.Drug and alcohol dependence, 153
R. Schuster, Natania Crane, R. Mermelstein, R. Gonzalez (2015)
Tobacco may mask poorer episodic memory among young adult cannabis users.Neuropsychology, 29 5
R. Maldonado, O. Valverde, F. Berrendero (2006)
Involvement of the endocannabinoid system in drug addictionTrends in Neurosciences, 29
Gillian Schauer, C. Berg, M. Kegler, D. Donovan, M. Windle (2016)
Differences in Tobacco Product Use Among Past Month Adult Marijuana Users and Nonusers: Findings From the 2003-2012 National Survey on Drug Use and Health.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 18 3
J. Cheer, K. Wassum, L. Sombers, M. Heien, J. Ariansen, Brandon Aragona, P. Phillips, R. Wightman (2007)
Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor ActivationThe Journal of Neuroscience, 27
Matthew Pava, J. Woodward (2012)
A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research.Alcohol, 46 3
F. Wagner, J. Anthony (2002)
Into the world of illegal drug use: exposure opportunity and other mechanisms linking the use of alcohol, tobacco, marijuana, and cocaine.American journal of epidemiology, 155 10
F. Filbey, Tim McQueeny, Shrinath Kadamangudi, Collette Bice, Ariel Ketcherside (2015)
Combined effects of marijuana and nicotine on memory performance and hippocampal volumeBehavioural Brain Research, 293
I. Svíženská, P. Dubový, A. Šulcová (2008)
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short reviewPharmacology Biochemistry and Behavior, 90
S. Gruber, D. Yurgelun-Todd (2005)
Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation.Brain research. Cognitive brain research, 23 1
Mark Rubinstein, Michelle Rait, J. Prochaska (2014)
Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers.Drug and alcohol dependence, 141
D. Fergusson, J. Boden, L. Horwood (2006)
Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis.Addiction, 101 4
The prevalence of comorbid cannabis and tobacco use has been increasing among adolescents and adults and has been shown to be associated with a range of changes or deficits in physical, psychological, and behavioral outcomes. Moreover, comorbid use has been shown to have a differential effect on the structure and function of the brain, especially as it relates to the reward circuitry and learning and memory. This interaction might be mediated by the involvement of the endocannabinoid system and alterations in dopamine signaling in regions associated with reward and cognitive functioning. While current findings demonstrate a differential effect of comorbid use on neurobiological and behavioral correlates compared with single substance use, additional studies are needed controlling for potential psychiatric comorbidities, age of onset of use, and use of other substances. Understanding the neurobiological mechanisms associated with comorbid cannabis and tobacco use will be important in developing successful treatment outcomes in the future.
Current Addiction Reports – Springer Journals
Published: Apr 7, 2016
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