Clozapine

Clozapine Reactions 1680, p94 - 2 Dec 2017 Neutropenia and leucopenia: 5 case reports In a retrospective cohort study, five men (aged 30-57 years) were described, who developed leucopenia or neutropenia during treatment with clozapine [route, dosage and outcomes not stated]. The men, who had schizophrenia, received treatment with clozapine. The patients developed leucopenia or neutropenia after 34 335 days of clozapine treatment. Out of these five patients, one developed neutropenia, one patient developed both leucopenia and neutropenia (two episodes) and three patients developed leucopenia of which one patient had three leucopenic episodes. At the start of episodes of leucopenia or neutropenia the patients had received clozapine 200 600mg. The patients discontinued clozapine due to leucopenia or neutropenia. However, three patients restarted clozapine after onset of leucopenia or neutropenia. Author comment: "We evaluated results of complete blood count monitoring to compare percentages of patients who developed or would have developed ≥1 hematologic event under the previous and current FDA guidelines in the first year following initiation of clozapine." "Further, clozapine-induced hematologic episodes that warrant discontinuation or interruption of treatment". "For this analysis, neutropenic and leukopenic events were defined according to FDA guidelines". Sultan RS, et al. Evaluating the effect of the changes in FDA guidelines for clozapine monitoring. Journal of Clinical Psychiatry 78: e933-e939, No. 8, Oct 2017. Available from: URL: http://doi.org/10.4088/JCP.16m11152 - USA 803285376 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Clozapine

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
Free
1 page

Loading next page...
1 Page
 
/lp/springer-journals/clozapine-Tqk9gvNhuT
Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39025-9
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p94 - 2 Dec 2017 Neutropenia and leucopenia: 5 case reports In a retrospective cohort study, five men (aged 30-57 years) were described, who developed leucopenia or neutropenia during treatment with clozapine [route, dosage and outcomes not stated]. The men, who had schizophrenia, received treatment with clozapine. The patients developed leucopenia or neutropenia after 34 335 days of clozapine treatment. Out of these five patients, one developed neutropenia, one patient developed both leucopenia and neutropenia (two episodes) and three patients developed leucopenia of which one patient had three leucopenic episodes. At the start of episodes of leucopenia or neutropenia the patients had received clozapine 200 600mg. The patients discontinued clozapine due to leucopenia or neutropenia. However, three patients restarted clozapine after onset of leucopenia or neutropenia. Author comment: "We evaluated results of complete blood count monitoring to compare percentages of patients who developed or would have developed ≥1 hematologic event under the previous and current FDA guidelines in the first year following initiation of clozapine." "Further, clozapine-induced hematologic episodes that warrant discontinuation or interruption of treatment". "For this analysis, neutropenic and leukopenic events were defined according to FDA guidelines". Sultan RS, et al. Evaluating the effect of the changes in FDA guidelines for clozapine monitoring. Journal of Clinical Psychiatry 78: e933-e939, No. 8, Oct 2017. Available from: URL: http://doi.org/10.4088/JCP.16m11152 - USA 803285376 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off