Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets

Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi... The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bioenergetics and Biomembranes Springer Journals

Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer Science+Business Media, LLC
Subject
Chemistry; Bioorganic Chemistry; Animal Biochemistry; Organic Chemistry; Biochemistry, general; Animal Anatomy / Morphology / Histology
ISSN
0145-479X
eISSN
1573-6881
DOI
10.1007/s10863-011-9331-1
Publisher site
See Article on Publisher Site

Abstract

The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose.

Journal

Journal of Bioenergetics and BiomembranesSpringer Journals

Published: Jan 27, 2011

References

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