213 86 86 1 2 Karen Thatcher Britton Janet Morgan Jean Rivier Wylie Vale George F. Koob Department of Psychiatry San Diego Veterans Administration Medical Center 92161 La Jolla CA USA UCSD School of Medicine 92161 La Jolla CA USA Peptide Biology Laboratory The Salk Institute PO Box 85800 92138 San Diego CA USA Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation Torrey Pines Road 10666 N La Jolla CA 92037 USA Abstract The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with “anxiety” or an increased responsiveness to stress.
Psychopharmacology – Springer Journals
Published: Mar 1, 1985
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