Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test

Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the... 213 86 86 1 2 Karen Thatcher Britton Janet Morgan Jean Rivier Wylie Vale George F. Koob Department of Psychiatry San Diego Veterans Administration Medical Center 92161 La Jolla CA USA UCSD School of Medicine 92161 La Jolla CA USA Peptide Biology Laboratory The Salk Institute PO Box 85800 92138 San Diego CA USA Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation Torrey Pines Road 10666 N La Jolla CA 92037 USA Abstract The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with “anxiety” or an increased responsiveness to stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test

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Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00431704
Publisher site
See Article on Publisher Site

Abstract

213 86 86 1 2 Karen Thatcher Britton Janet Morgan Jean Rivier Wylie Vale George F. Koob Department of Psychiatry San Diego Veterans Administration Medical Center 92161 La Jolla CA USA UCSD School of Medicine 92161 La Jolla CA USA Peptide Biology Laboratory The Salk Institute PO Box 85800 92138 San Diego CA USA Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation Torrey Pines Road 10666 N La Jolla CA 92037 USA Abstract The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with “anxiety” or an increased responsiveness to stress.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1985

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