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Characterization of the receptor mediating the nicotine discriminative stimulus

Characterization of the receptor mediating the nicotine discriminative stimulus 213 74 74 4 4 Carmelo Romano Avram Goldstein Nicholas P. Jewell Addiction Research Foundation 94304 Palo Alto California USA Department of Pharmacology Stanford University School of Medicine 94305 Stanford California USA Department of Family, Community, and Preventive Medicine Stanford University School of Medicine 94305 Stanford California USA Department of Pharmacology Yale University School of Medicine 333 Cedar Street 06510 New Haven CT USA Department of Statistics Princeton University Fine Hall PO Box 37 08540 Princeton NJ USA Abstract The discriminative stimulus (cue) property of nicotine was studied in a T-maze paradigm, and the results were analyzed by a new statistical method. For rats trained on 0.4 mg/kg, the ED 50 was 0.11 mg/kg. The enantinomer of natural nicotine (+)nicotine was much less potent, and both position isomers of nicotine were inactive. Anabasine, which is active at nicotinic cholinergic receptors, provided the nicotine cue. Cytisine, a potent nicotinic agonist in vitro, was ineffective after SC administration and this was shown to be due to its inability to enter the brain in adequate amounts. High doses of cytisine by the intracerebroventricular route partially provided the cue. The cue was blocked by low doses of mecamylamine and pempidine and by high doses of hexamethonium. The data indicate that the cue receptor is pharmacologically similar to the nicotinic cholinergic receptor in autonomic ganglia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Characterization of the receptor mediating the nicotine discriminative stimulus

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00432737
Publisher site
See Article on Publisher Site

Abstract

213 74 74 4 4 Carmelo Romano Avram Goldstein Nicholas P. Jewell Addiction Research Foundation 94304 Palo Alto California USA Department of Pharmacology Stanford University School of Medicine 94305 Stanford California USA Department of Family, Community, and Preventive Medicine Stanford University School of Medicine 94305 Stanford California USA Department of Pharmacology Yale University School of Medicine 333 Cedar Street 06510 New Haven CT USA Department of Statistics Princeton University Fine Hall PO Box 37 08540 Princeton NJ USA Abstract The discriminative stimulus (cue) property of nicotine was studied in a T-maze paradigm, and the results were analyzed by a new statistical method. For rats trained on 0.4 mg/kg, the ED 50 was 0.11 mg/kg. The enantinomer of natural nicotine (+)nicotine was much less potent, and both position isomers of nicotine were inactive. Anabasine, which is active at nicotinic cholinergic receptors, provided the nicotine cue. Cytisine, a potent nicotinic agonist in vitro, was ineffective after SC administration and this was shown to be due to its inability to enter the brain in adequate amounts. High doses of cytisine by the intracerebroventricular route partially provided the cue. The cue was blocked by low doses of mecamylamine and pempidine and by high doses of hexamethonium. The data indicate that the cue receptor is pharmacologically similar to the nicotinic cholinergic receptor in autonomic ganglia.

Journal

Psychopharmacology – Springer Journals

Published: Sep 1, 1981

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