Central Mechanisms of HPA Axis Regulation by Voluntary Exercise

Central Mechanisms of HPA Axis Regulation by Voluntary Exercise Stress exerts complex effects on the brain and periphery, dependent on the temporal profile and intensity of the stressor. The consequences of a stressful event can also be determined by other characteristics of the stressor, such as whether it is predictable and controllable. While the traditional view has focused primarily on the negative effects of stress on a variety of somatic systems, emerging data support the idea that certain forms of stress can enhance cellular function. Here we review the current literature on the hypothalamic-pituitary-adrenal (HPA) axis regulation by wheel running, a voluntary and controllable stressor with a distinct temporal profile. While running indeed activates a number of systems related to the stress response, other mechanisms exist to reduce the reactivity to this stressor, with possible crosstalk between running and other forms of stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png NeuroMolecular Medicine Springer Journals

Central Mechanisms of HPA Axis Regulation by Voluntary Exercise

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Publisher
Springer Journals
Copyright
Copyright © 2008 by Humana Press
Subject
Medicine & Public Health; Internal Medicine ; Neurology ; Medicine/Public Health, general
ISSN
1535-1084
eISSN
1559-1174
DOI
10.1007/s12017-008-8027-0
pmid
18273712
Publisher site
See Article on Publisher Site

Abstract

Stress exerts complex effects on the brain and periphery, dependent on the temporal profile and intensity of the stressor. The consequences of a stressful event can also be determined by other characteristics of the stressor, such as whether it is predictable and controllable. While the traditional view has focused primarily on the negative effects of stress on a variety of somatic systems, emerging data support the idea that certain forms of stress can enhance cellular function. Here we review the current literature on the hypothalamic-pituitary-adrenal (HPA) axis regulation by wheel running, a voluntary and controllable stressor with a distinct temporal profile. While running indeed activates a number of systems related to the stress response, other mechanisms exist to reduce the reactivity to this stressor, with possible crosstalk between running and other forms of stress.

Journal

NeuroMolecular MedicineSpringer Journals

Published: Feb 14, 2008

References

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