Cellulite: An Evidence-Based Review

Stefanie Luebberding; Nils Krueger; Neil Sadick

doi:10.1007/s40257-015-0129-5

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Publisher: Springer Journals
Copyright: Copyright © 2015 by Springer International Publishing Switzerland
Subject: Medicine & Public Health; Dermatology; Pharmacotherapy; Pharmacology/Toxicology
ISSN: 1175-0561
eISSN: 1179-1888
DOI: 10.1007/s40257-015-0129-5
pmid: 25940753
Publisher site: See Article on Publisher Site

Abstract

Am J Clin Dermatol (2015) 16:243–256 DOI 10.1007/s40257-015-0129-5 EVIDENCE-BASED REVIEW 1 1 2 • • Stefanie Luebberding Nils Krueger Neil S. Sadick Published online: 5 May 2015 Springer International Publishing Switzerland 2015 Abstract acoustic wave therapy (AWT) and the 1440 nm Nd:YAG Background Cellulite is a multifactorial condition that is minimally invasive laser. present in 80–90 % of post-pubertal women. Despite its Conclusion This article provides a systematic evaluation high prevalence, it remains a major cosmetic concern for of the scientiﬁc evidence of the efﬁcacy of treatment for women. A wide range of products and treatments for cel- cellulite reduction. No clear evidence of good efﬁcacy lulite reduction is available; however, no systematic review could be identiﬁed in any of the evaluated cellulite has been performed so far to evaluate the efﬁcacy of the treatments. available treatment options for cellulite. Objective The objective of this review is to provide a systematic evaluation of the scientiﬁc evidence of the ef- Key Points ﬁcacy of treatments for cellulite reduction. Methods This systematic review followed the PRISMA No biophysical measurement exists with which to guidelines for reporting systematic reviews and meta-ana- evaluate cellulite. lyses. Only original articles in English or German reporting

Journal

American Journal of Clinical Dermatology – Springer Journals

Published: May 5, 2015

References

So-called cellulite: an invented disease

Nürnberger, F; Müller, G
Cellulite: from standing fat herniation to hypodermal stretch marks

Piérard, GE; Nizet, JL; Piérard-Franchimont, C
Cellulite: advances in treatment: facts and controversies

Emanuele, E
Cellulite treatment using a novel combination radiofrequency, infrared light, and mechanical tissue manipulation device

Alster, TS; Tanzi, EL
A study evaluating the safety and efficacy of the VelaSmooth system in the treatment of cellulite

Sadick, N; Magro, C
Reduction of subcutaneous fat and improvement in cellulite appearance by dual-wavelength, low-level laser energy combined with vacuum and massage

Lach, E
Effect of weight loss on cellulite: gynoid lypodystrophy

Smalls, LK; Hicks, M; Passeretti, D; Gersin, K; Kitzmiller, WJ; Bakhsh, A; Wickett, RR; Whitestone, J; Visscher, MO
Single treatment of grades II and III cellulite using a minimally invasive 1,440-nm pulsed Nd:YAG laser and side-firing fiber: an institutional review board-approved study with a 24-month follow-up period

Sasaki, GH
Long-wave infrared radiation reflected by compression stockings in the treatment of cellulite: a clinical double-blind, randomized and controlled study

Bagatin, E; Miot, HA; Soares, JLM; Sanudo, A; Afonso, JPJM; de Barros Junior, N; Talarico, S
A double-blind evaluation of the activity of an anti-cellulite product containing retinol, caffeine, and ruscogenine by a combination of several non-invasive methods

Bertin, C; Zunino, H; Pittet, JC; Beau, P; Pineau, P; Massonneau, M; Robert, C; Hopkins, J
Evaluation of anti-cellulite efficacy: a topical cosmetic treatment for cellulite blemishes - a multifunctional formulation

Sparavigna, A; Guglielmini, G; Togni, S; Cristoni, A; Maramaldi, G
A validated photonumeric cellulite severity scale

Hexsel, DM; Dal’forno, T; Hexsel, CL
Non-invasive evaluation techniques to quantify the efficacy of cosmetic anti-cellulite products

Bielfeldt, S; Buttgereit, P; Brandt, M; Springmann, G; Wilhelm, K-P
Cellulite: a review of its physiology and treatment

Avram, MM
Cellulite—an overview of non-invasive therapy with energy-based systems

Gold, MH
Treatment of cellulite: Part II. Advances and controversies

Khan, MH; Victor, F; Rao, B; Sadick, NS
Cellulite—the greatest skin problem in healthy people? An approach

Pavicic, T; Borelli, C; Korting, HC
Laser, light, and energy devices for cellulite and lipodystrophy

Peterson, JD; Goldman, MP
Cellulite

Proebstle, TM
Cellulite and its treatment

Rawlings, AV
Cellulite: a review

Rossi, AB; Vergnanini, AL
A modern approach to the treatment of cellulite

Rossi, AM; Katz, BE
An assessment of traditional and novel therapies for cellulite

Vliet, M; Ortiz, A; Avram, MM; Yamauchi, PS
An evidence-based assessment of treatments for cellulite

Wanner, M; Avram, M
The science of cellulite treatment and its long-term effectiveness

Wassef, C; Rao, BK
Treatment of cellulite with LPG endermologie

Güleç, AT
Noninvasive mechanical body contouring: (endermologie) a one-year clinical outcome study update

Chang, P; Wiseman, J; Jacoby, T; Salisbury, AV; Ersek, RA
An exploratory investigation of the morphology and biochemistry of cellulite

Rosenbaum, M; Prieto, V; Hellmer, J; Boschmann, M; Krueger, J; Leibel, RL; Ship, AG
An alternative treatment modality for cellulite: LPG endermologie

Kutlubay, Z; Songur, A; Engin, B; Khatib, R; Calay, Ö; Serdaroğlu, S
Longitudinal evaluation of manual lymphatic drainage for the treatment of gynoid lipodystrophy

Schonvvetter, B; Soares, JLM; Bagatin, E
Caffeine’s mechanisms of action and its cosmetic use

Herman, A; Herman, AP
Antiadipogenic properties of retinol in primary cultured differentiating human adipocyte precursor cells

Garcia, E; Lacasa, D; Agli, B; Giudicelli, Y; Castelli, D
Expression studies of key adipogenic transcriptional factors reveal that the anti-adipogenic properties of retinol in primary cultured human preadipocytes are due to retinol per se

Machinal-Quélin, F; Dieudonné, MN; Leneveu, MC; Pecquery, R; Castelli, D; Oddos, T; Giudicelli, Y
A randomized, placebo-controlled trial of topical retinol in the treatment of cellulite

Piérard-Franchimont, C; Piérard, GE; Henry, F; Vroome, V; Cauwenbergh, G
Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy

Al-Bader, T; Byrne, A; Gillbro, J; Mitarotonda, A; Metois, A; Vial, F; Rawlings, AV; Laloeuf, A
Prospective and randomized determination of the efficacy of topical lipolytic agents

Epstein, E; Young, VL; Schorr, M; Young, AE; Weisenborn, S
Topical retinol improves cellulite

Kligman, A; Pagnoni, A; Stoudemayer, T
Modification of subcutaneous adipose tissue by a methylxanthine formulation: a double-blind controlled study

Lesser, T; Ritvo, E; Moy, LS
Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies

Roure, R; Oddos, T; Rossi, A; Vial, F; Bertin, C
Evaluation of the effects of caffeine in the microcirculation and edema on thighs and buttocks using the orthogonal polarization spectral imaging and clinical parameters

Lupi, O; Semenovitch, IJ; Treu, C; Bottino, D; Bouskela, E
In vitro and in vivo efficacy of sulfo-carrabiose, a sugar-based cosmetic ingredient with anti-cellulite properties

Vogelgesang, B; Bonnet, I; Godard, N; Sohm, B; Perrier, E
Cellulite treatment: a myth or reality: a prospective randomized, controlled trial of two therapies, endermologie and aminophylline cream

Collis, N; Elliot, LA; Sharpe, C; Sharpe, DT
Imaging of the skin and subcutaneous tissue using classical and high-frequency ultrasonographies in anti-cellulite therapy

Mlosek, RK; Dębowska, RM; Lewandowski, M; Malinowska, S; Nowicki, A; Eris, I
The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite: a randomized, double-blinded study

Sasaki, GH; Oberg, K; Tucker, B; Gaston, M
Efficacy of cosmetic products in cellulite reduction: systematic review and meta-analysis

Turati, F; Pelucchi, C; Marzatico, F; Ferraroni, M; Decarli, A; Gallus, S; Vecchia, C; Galeone, C
A two-center, double-blinded, randomized trial testing the tolerability and efficacy of a novel therapeutic agent for cellulite reduction

Rao, J; Gold, MH; Goldman, MP
Use of intense pulsed light and a retinyl-based cream as a potential treatment for cellulite: a pilot study

Fink, JS; Mermelstein, H; Thomas, A; Trow, R
Impact of extracorporeal shock waves on the human skin with cellulite: a case study of an unique instance

Kuhn, C; Angehrn, F; Sonnabend, O; Voss, A
Physical-technical principles of extracorporeal shockwave therapy (ESWT)

Gerdesmeyer, L; Maier, M; Haake, M; Schmitz, C
Can cellulite be treated with low-energy extracorporeal shock wave therapy?

Angehrn, F; Kuhn, C; Voss, A
Principles of shock wave therapy

Ogden, JA; Tóth-Kischkat, A; Schultheiss, R
Improvement in skin elasticity in the treatment of cellulite and connective tissue weakness by means of extracorporeal pulse activation therapy

Christ, C; Brenke, R; Sattler, G; Siems, W; Novak, P; Daser, A
Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

Siems, W; Grune, T; Voss, P; Brenke, R
Controlled, randomized study evaluating the effects of treating cellulite with AWT/EPAT

Adatto, M; Adatto-Neilson, R; Servant, J-J; Vester, J; Novak, P; Krotz, A
Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT®) for cellulite treatment

Russe-Wilflingseder, K; Russe-Wilfingsleder, K; Russe, E; Vester, JC; Haller, G; Novak, P; Krotz, A
Cellulite and focused extracorporeal shockwave therapy for non-invasive body contouring: a randomized trial

Knobloch, K; Joest, B; Krämer, R; Vogt, PM
The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review

Mani-Babu, S; Morrissey, D; Waugh, C; Screen, H; Barton, C
Meta-analysis of high-energy extracorporeal shock wave therapy in recalcitrant plantar fasciitis

Zhiyun, L; Tao, J; Zengwu, S
Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: a meta-analysis of RCTs

Aqil, A; Siddiqui, MRS; Solan, M; Redfern, DJ; Gulati, V; Cobb, JP
Clinical improvement and resorption of calcifications in calcific tendinitis of the shoulder after shock wave therapy at 6 months’ follow-up: a systematic review and meta-analysis

Ioppolo, F; Tattoli, M; Sante, L; Venditto, T; Tognolo, L; Delicata, M; Rizzo, RS; Tanna, G; Santilli, V
Nonablative laser resurfacing using the long-pulse (1064-nm) Nd:YAG laser

Dayan, SH; Vartanian, AJ; Menaker, G; Mobley, SR; Dayan, AN
Assessment of the efficacy of nonablative long-pulsed 1064-nm Nd:YAG laser treatment of wrinkles compared at 2, 4, and 6 months

Trelles, MA; Alvarez, X; Martín-Vázquez, MJ; Trelles, O; Velez, M; Levy, JL; Allones, I
Nonablative 1,064-nm Nd:YAG laser for treating atrophic facial acne scars: histologic and clinical analysis

Keller, R; Belda Júnior, W; Valente, NYS; Rodrigues, CJ
Effects of intense pulsed light and the 1,064 nm Nd:YAG laser on sun-damaged human skin: histologic and immunohistochemical analysis

Prieto, VG; Diwan, AH; Shea, CR; Zhang, P; Sadick, NS
Evaluation of a long pulsed 1064-nm Nd:YAG laser for improvement in appearance of cellulite

Truitt, A; Elkeeb, L; Ortiz, A; Saedi, N; Echague, A; Kelly, KM
High-frequency ultrasound evaluation of cellulite treated with the 1064 nm Nd:YAG laser

Bousquet-Rouaud, R; Bazan, M; Chaintreuil, J; Echague, AV
Treatment of cellulite using a 1440-nm pulsed laser with one-year follow-up

DiBernardo, BE
A multicenter study for a single, three-step laser treatment for cellulite using a 1440-nm Nd:YAG laser, a novel side-firing fiber, and a temperature-sensing cannula

DiBernardo, B; Sasaki, G; Katz, BE; Hunstad, JP; Petti, C; Burns, AJ
Quantitative and qualitative evaluation of the efficacy of a 1440 nm Nd:YAG laser with novel bi-directional optical fiber in the treatment of cellulite as measured by 3-dimensional surface imaging

Katz, B
Cellulite: a new treatment approach combining subdermal Nd: YAG laser lipolysis and autologous fat transplantation

Goldman, A; Gotkin, RH; Sarnoff, DS; Prati, C; Rossato, F
Effect of 635 nm low-level laser therapy on upper arm circumference reduction

Nestor, MS; Zarraga, MB; Park, H
Do laser and led phototherapies influence mast cells and myofibroblasts to produce collagen?

Castro, ICV; Rocha, CAG; Gomes Henriques, AC; Cavalcanti de Sousa, AP; Lisboa, MV; Sotero D da, R; Pinheiro, ALB; Cury, PR; Santos, JND
A single center, randomized, comparative, prospective clinical study to determine the efficacy of the VelaSmooth system versus the Triactive system for the treatment of cellulite

Nootheti, PK; Magpantay, A; Yosowitz, G; Calderon, S; Goldman, MP
A double-blind, placebo-controlled randomized trial evaluating the ability of low-level laser therapy to improve the appearance of cellulite

Jackson, RF; Roche, GC; Shanks, SC
Low-level laser therapy and vibration therapy for the treatment of localized adiposity and fibrous cellulite

Savoia, A; Landi, S; Vannini, F; Baldi, A
Effect of NASA light-emitting diode irradiation on wound healing

Whelan, HT; Smits, RL; Buchman, EV; Whelan, NT; Turner, SG; Margolis, DA; Cevenini, V; Stinson, H; Ignatius, R; Martin, T; Cwiklinski, J; Philippi, AF; Graf, WR; Hodgson, B; Gould, L; Kane, M; Chen, G; Caviness, J
New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training

Paolillo, FR; Borghi-Silva, A; Parizotto, NA; Kurachi, C; Bagnato, VS
Selective photothermolysis of lipid-rich tissues: a free electron laser study

Anderson, RR; Farinelli, W; Laubach, H; Manstein, D; Yaroslavsky, AN; Gubeli, J; Jordan, K; Neil, GR; Shinn, M; Chandler, W; Williams, GP; Benson, SV; Douglas, DR; Dylla, HF
Fat liquefaction: effect of low-level laser energy on adipose tissue

Neira, R; Arroyave, J; Ramirez, H; Ortiz, CL; Solarte, E; Sequeda, F; Gutierrez, MI
Reduction in thigh circumference and improvement in the appearance of cellulite with dual-wavelength, low-level laser energy and massage

Gold, MH; Khatri, KA; Hails, K; Weiss, RA; Fournier, N
Evaluation of a noninvasive, dual-wavelength laser-suction and massage device for the regional treatment of cellulite

Kulick, MI
Noninvasive treatment of cellulite utilizing an expedited treatment protocol with a dual wavelength laser-suction and massage device

Hexsel, D; Siega, C; Schilling-Souza, J; Oliveira, DH
Effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs

Emilia del Pino, M; Rosado, RH; Azuela, A; Graciela Guzmán, M; Argüelles, D; Rodríguez, C; Rosado, GM
A multicenter study of cellulite treatment with a variable emission radio frequency system

Lugt, C; Romero, C; Ancona, D; Al-Zarouni, M; Perera, J; Trelles, MA
Clinical and histopathological study of the TriPollar home-use device for body treatments

Boisnic, S; Branchet, M-C; Birnstiel, O; Beilin, G
Nonablative radiofrequency treatment of facial laxity

Fisher, GH; Jacobson, LG; Bernstein, LJ; Kim, KH; Geronemus, RG
Circumference reduction and cellulite treatment with a TriPollar radiofrequency device: a pilot study

Manuskiatti, W; Wachirakaphan, C; Lektrakul, N; Varothai, S
The effectiveness of anticellulite treatment using tripolar radiofrequency monitored by classic and high-frequency ultrasound

Mlosek, RK; Woźniak, W; Malinowska, S; Lewandowski, M; Nowicki, A
Unipolar radiofrequency treatment to improve the appearance of cellulite

Alexiades-Armenakas, M; Dover, JS; Arndt, KA
Clinical, laboratory, and MRI analysis of cellulite treatment with a unipolar radiofrequency device

Goldberg, DJ; Fazeli, A; Berlin, AL
Effects of cellulite treatment with RF, IR light, mechanical massage and suction treating one buttock with the contralateral as a control

Romero, C; Caballero, N; Herrero, M; Ruíz, R; Sadick, NS; Trelles, MA
A bipolar radiofrequency, infrared, vacuum and mechanical massage device for treatment of cellulite: a pilot study

Hexsel, DM; Siega, C; Schilling-Souza, J; Porto, MD; Rodrigues, TC
Evaluation of the combination of radio frequency, infrared energy and mechanical rollers with suction to improve skin surface irregularities (cellulite) in a limited treatment area

Kulick, M
A prospective clinical study to evaluate the efficacy and safety of cellulite treatment using the combination of optical and RF energies for subcutaneous tissue heating

Sadick, NS; Mulholland, RS
Treatment of cellulite with a bipolar radiofrequency, infrared heat, and pulsatile suction device: a pilot study

Wanitphakdeedecha, R; Manuskiatti, W
Treatment of cellulite with optical devices: an overview with practical considerations

Alster, TS; Tehrani, M
Ultrastructural assessment of cellulite morphology: clues to a therapeutic strategy?

Omi, T; Sato, S; Kawana, S
Efficacy of a multifunctional plant complex in the treatment of the so-called “cellulite”: clinical and instrumental evaluation

Distante, F; Bacci, PA; Carrera, M
Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite

Lis-Balchin, M
Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite

Savikin, K; Menković, N; Zdunić, G; Pljevljakušić, D; Spasić, S; Kardum, N; Konić-Ristić, A
Carbon dioxide therapy in the treatment of cellulite: an audit of clinical practice

Lee, GSK
Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations

Brandi, C; D’Aniello, C; Grimaldi, L; Bosi, B; Dei, I; Lattarulo, P; Alessandrini, C
A double-blinded randomized trial testing the tolerability and efficacy of a novel topical agent with and without occlusion for the treatment of cellulite: a study and review of the literature

Rao, J; Paabo, KE; Goldman, MP
Effect of ultrasound and hyaluronidase on gynoid lipodystrophy type II—an ultrasonography study

Da Silva, CM; Mello Pinto, MV; Barbosa, LG; Filho, SDDS; Rocha, LLV; Gonçalves, RV
Subcutaneous incisionless (subcision) surgery for the correction of depressed scars and wrinkles

Orentreich, DS; Orentreich, N
Subcision: a treatment for cellulite

Hexsel, DM; Mazzuco, R

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Cellulite: An Evidence-Based Review

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Cellulite: An Evidence-Based Review

Cellulite: An Evidence-Based Review

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