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Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone

Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial... Purpose. For selective inhibition of endothelial cell activation in chronic inflammation, we have developed a dexamethasone-anti-E-selectin immunoconjugate. The present study was performed to evaluate the cellular handling of this immunoconjugate by activated primary endothelial cells and to compare its drug delivery capacity with free dexamethasone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2002 by Plenum Publishing Corporation
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
DOI
10.1023/A:1020769716288
Publisher site
See Article on Publisher Site

Abstract

Purpose. For selective inhibition of endothelial cell activation in chronic inflammation, we have developed a dexamethasone-anti-E-selectin immunoconjugate. The present study was performed to evaluate the cellular handling of this immunoconjugate by activated primary endothelial cells and to compare its drug delivery capacity with free dexamethasone.

Journal

Pharmaceutical ResearchSpringer Journals

Published: Oct 10, 2004

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