- Publisher site
- See Article on Publisher Site
Abstract
Cyclin-dependent kinases (CDK) form a conserved superfamily of eukaryotic serine-threonine protein kinases, which require binding to a cyclin protein for activity. CDK are involved in different aspects of cell biology and notably in cell cycle regulation. The comparison of nearly 50 plant CDK-related cDNAs with a selected set of their animal and yeast counterparts reveals five classes of these genes in plants. These are described here with respect to their phylogenetic, structural and functional properties. A plant-wide nomenclature of CDK-related genes is proposed, using a system similar to that of the plant cyclin genes. The most numerous class, CDKA, includes genes coding for CDK with the PSTAIRE canonical motif. CDKB makes up a class of plant-specific CDK divided into two groups: CDKB1 and CDKB2. CDKC, CDKD and CDKE form less numerous classes. The CDKD class includes the plant orthologues of metazoan CDK7, which correspond to the CDK-activating kinase (CAK). At present, no functional information is available in plants for CDKC and CDKE.
Journal
Plant Molecular Biology – Springer Journals
Published: Oct 16, 2004
Recommended Articles
Loading...
References
-
The cyclin family of budding yeast: abundant use of a good ideaAndrews, B.; Measday, V.
-
Crystal structure of the complex of the cyclin D dependent kinase Cdk6 bound to the cell-cycle inhibitor p19(INK4d)Brotherton, D.H.; Dhanaraj, V.; Wick, S.; Brizuela, L.; Domaille, P.J.; Volyanik, E.; Xu, X.; Parisini, E.; Smith, B.O.; Archer, S.J.; Serrano, M.; Brenner, S.L.; Blundell, T.L.; Laue, E.D.
-
The cell cycle in ArabidopsisBurssens, S.; Van Montagu, M.; Inzé, D.
-
Auxin-cytokinin interactions in higher plants: old problems and new toolsCoenen, C.; Lomax, T.L.
-
Identification and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea maysColasanti, J.; Tyers, M.; Sundaresan, V.
-
Crystal structure of cyclin-dependent kinase 2DeBondt, H.L.; Rosenblatt, J.; Jancarik, J.; Jones, H.D.; Morgan, D.O.; Kim, S.H.
-
CDK9 (PITALRE): a multifunctional cdc2-related kinaseDefalco, G.; Giordano, A.
-
The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAtDeveylder, L.; Segers, G.; Glab, N.; Casteels, P.; Van Montagu, M.; Inzé, D.
-
Identification of proteins interacting with the Arabidopsis Cdc2aAt proteinDeveylder, L.; Segers, G.; Glab, N.; Van Montagu, M.; Inzé, D.
-
cdc2 phosphorylation is required for its interaction with cyclinDucommun, B.; Brambilla, P.; Felix, M. A.; Franza, B.; Karsenti, E.; Draetta, G.
-
Plant Cell DivisionDudits, D.; Magyar, Z.; Deak, M.; Meszaros, T.; Miskolczi, P.; Feher, A.; Brown, S.; Kondorosi, E.; Athanasiadis, A.; Pongor, S.; Bako, L.; Koncz, C.; Gyorgyey, J.
-
Regulation of transcription by proteins that control the cell cycleDynlacht, B.D.
-
A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAKEspinoza, F.H.; Farrell, A.; Erdjument-Bromage, H.; Tempst, P.; Morgan, D.O.
-
Cloning of the pea cdc2 homologue by efficient immunological screening of PCR productsFeiler, H.; Jacobs, T.
-
The Arabidopsis functional homolog of the p34cdc2 protein kinaseFerreira, P.C.G.; Hemerly, A.S.; Villaroel, R.; Van Montagu, M.; Inzé, D.
-
Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plantsFobert, P.R.; Gaudin, V.; Lunness, P.; Coen, E.S.; Doonan, J.H.
-
Plant cell morphogenesis: plasma membrane interactions with the cytoskeleton and cell wallFowler, J.E.; Quatrano, R.S.
-
The plant cell cycleFrancis, D.; Halford, N.G.
-
Protein kinasesGoldsmith, E.J.; Cobb, M.H.
-
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplicationGrafi, G.; Burnett, R.J.; Helentjaris, T.; Larkins, B.A.; Decaprio, J.A.; Sellers, W.R.; Kaelin, W.G.
-
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsHanks, S.K.; Quinn, A.M.; Hunter, T.
-
The role of Cdk7 in CAK function, a retro-retrospectiveHarper, J.W.; Elledge, S.J.
-
Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variantsHashimoto, J.; Hirabayashi, T.; Hayano, Y.; Hata, S.; Ohashi, Y.; Suzuka, I; Utsugi, T.; Toh-E, A.; Kikuchi, Y.
-
cDNA cloning of a novel cdc2+/CDC28-related protein kinase from riceHata, S.
-
Isolation and characterization of cDNA clones for plant cyclinsHata, S.; Kouchi, H.; Suzuka, I.; Ishii, T.
-
Cytokinesis in flowering plants: cellular process and developmental integrationHeese, M.; Mayer, U.; Jurgens, G.
-
Genes regulating the plant cell cycle: isolation of a mitotic-like cyclin from Arabidopsis thalianaHemerly, A.; Bergounioux, C.; Van Montagu, M.; Inzé, D.; Ferreira, P.
-
cdc2a expression in Arabidopsis is linked with the competence for cell divisionHemerly, A.S.; Ferreira, P.J.E.; Van Montagu, M.; Engler, G.; Inzé, D.
-
cdc2MsB, a cognate cdc2 gene from alfalfa, complements the G1/S but not the G2/M transition of budding yeast cdc28 mutantsHirt, H.; Pay, A.; Bogre, L.; Meskiene, I.; Heberle-Bors, E.
-
Complementation of a yeast cell cycle mutant by an alfalfa cDNA encoding a protein kinase homologous to p34cdc2Hirt, H.; Pay, A.; Gyorgyev, J.; Bako, L.; Nemeth, K.; Bogre, L.; Schweyen, R. J.; Heberle-Bors, E.; Dudits, D.
-
p34cdc2 protein kinase homolog from mothbean (Vigna aconitifolia)Hong, Z.; Miao, G.; Verma, D.
-
The protein kinases of budding yeast: six score and moreHunter, T.; Plowman, G.D.
-
Exonintron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2bImajuku, Y.; Hirayama, T.; Endoh, H.; Oka, A.
-
Cell cycle controlJacobs, T.W.
-
Mechanism of cdk activation revealed by the structure of a cyclinA-CDK2 complexJeffrey, P.D.; Russo, A.A.; Polyak, K.; Gibbs, E.; Hurwitz, J.; Massagué, J.; Pavletich, N.P.
-
Molecular and biochemical characterization of the involvement of cyclin-dependent kinase A during the early development of tomato fruitJoubès, J.; Phan, T.H.; Just, D.; Rothan, C.; Bergounioux, C.; Raymond, P.; Chevalier, C.
-
The cdk-activating kinase (CAK): from yeast to mammalsKaldis, P.
-
Nucleotide sequence of rice (Oryza sativa L.) cDNA homologous to cdc2 geneKidou, S.; Umeda, M.; Uchimiya, H.
-
A cdc2 homologue and closely related processed retropseudogenes from Norway spruceKvarnheden, A.; Tandre, K.; Engstrom, P.
-
Molecular evolution of cdc2 pseudogenes in spruce (Picea)Kvarnheden, A.; Albert, V.A.; Engstrom, P.
-
Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesisLapidot-Lifson, Y.; Patinkin, D.; Prody, C.A.; Ehrlich, G.; Seidman, S.; Ben-Aziz, R.; Benseler, F.; Eckstein, F.; Zakut, H.; Soreq, H.
-
Signaling phosphate starvationLenburg, M.E.; Oshea, E.K.
-
Gene activation by UV light, fungal elicitor or fungal infection in Petroselinum crispum is correlated with repression of cell cycle-related genesLogemann, E.; Wu, S.C.; Schroder, J.; Schmelzer, E.; Somssich, I.E.; Hahlbrock, K.
-
Adventitious root growth and cell-cycle induction in deepwater riceLorbiecke, R.; Sauter, M.
-
Cell cycle phase specificity of putative cyclin-dependent kinase variants in synchronized alfalfa cellsMagyar, Z.; Meszaros, T.; Miskolczi, P.; Deak, M.; Feher, A.; Brown, S.; Kondorosi, E.; Athanasiadis, A.; Pongor, S.; Bilgin, M.; Bako, L.; Koncz, C.; Dudits, D.
-
Spatial pattern of cdc2 expression in relation to meristem activity and cell proliferation during plant developmentMartinez, M.C.; Jorgensen, J.E.; Lawton, M.A.; Lamb, C.J.; Doerner, P.W.
-
Regulation of cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiaeMendenhall, M.D.; Hodge, A.E.
-
Genetic control of cell division patterns in developing plantsMeyerowitz, E.M.
-
A family of human cdc2-related protein kinasesMeyerson, M.; Enders, G.H.; Wu, C.L.; Su, L.K.; Gorka, C.; Nelson, C.; Harlow, E.; Tsai, L.H.
-
Two functional soybean genes encoding p34cdc2 protein kinases are regulated by different plant developmental pathwaysMiao, G.; Hong, Z.; Verma, D.
-
Isolation and characterization of a cdc2 cDNA from Dictyostelium discoideumMichaelis, C.; Weeks, G.
-
Cyclin-dependent kinases and cell division in plants: the nexusMironov, V.; Deveylder, L.; Van Montagu, M.; Inzé, D.
-
Cyclin-dependent kinases: engines, clocks, and microprocessorsMorgan, D.O.
-
Tobacco retinoblastoma-related protein phosphorylated by a distinct cyclin-dependent kinase complex with Cdc2/cyclin D in vitroNakagami, H.; Sekine, M.; Murakami, H.; Shinmyo, A.
-
Genes galore: a summary of methods for accessing results from large-scale partial sequencing of anonymous Arabidopsis cDNA clonesNewman, T.; de Bruijn, F.J.; Green, P.; Keegstra, K.; Kende, H.; McIntosh, L.; Ohlrogge, J.; Raikhel, N.; Somerville, S.; Thomashow, M.; Retzel, E.; Somerville, C.
-
Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycleNigg, E.A.
-
Animal cell cycles and their controlNorbury, C.; Nurse, P.
-
Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cellsPorat, R.; Lu, P.Z.; Oneill, S.D.
-
A guide to naming sequenced plant genesPrice, C.A.; Reardon, E.M.; Lonsdale, D.M.
-
Plant cyclins: a unified nomenclature for plant A-, B-and D-type cyclins based on sequence organizationRenaudin, J.P.; Doonan, J.H.; Freeman, D.; Hashimoto, J.; Hirt, H.; Inzé, D.; Jacobs, T.; Kouchi, H.; Rouze, P.; Sauter, M.; Savoure, A.; Sorrell, D. A.; Sundaresan, V.; Murray, J.A.H.
-
Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase IIRickert, P.; Seghezzi, W.; Shanahan, F.; Cho, H.; Lees, E.
-
Crystal structure of the p27(Kip1) cyclin-dependentkinase inhibitor bound to the cyclin A Cdk2 complexRusso, A.A.; Jeffrey, P.D.; Patten, A.K.; Massague, J.; Pavletich, N.P.
-
Structural basis of cyclin-dependent kinase activation by phosphorylationRusso, A.A.; Jeffrey, P.D.; Pavletich, N.P.
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a)Russo, A.A.; Tong, L.; Lee, J.O.; Jeffrey, P.D.; Pavletich, N.P.
-
Differential expression of a CAK (cdc2-activating kinase)-like protein kinase, cyclins and cdc2 genes from rice during the cell cycle and in response to gibberellinSauter, M.
-
The Arabidopsis cyclin-dependent kinase gene cdc2bAt is preferentially expressed during S and G(2) phases of the cell cycleSegers, G.; Gadisseur, I.; Bergounioux, C.; Engler, J.D.; Jacqmard, A.; Van Montagu, M.; Inzé, D.
-
Association of CDKactivating kinase subunits with transcription factor TFIIHSerizawa, H.; Makela, T.P.; Conaway, J.W.; Conaway, R.C.; Weinberg, R.A.; Young, R.A.
-
Molecular cloning and characterization of a cDNA clone that encodes a Cdc2 homolog from Nicotiana tabacumSetiady, Y.Y.; Sekine, M.; Hariguchi, N.; Kouchi, H.; Shinmyo, A.
-
Regulation of cell division in ArabidopsisShaul, O.; Van Montagu, M.; Inzé, D.
-
Analysis of cycles of dormancy and growth in pea axillary buds based on mRNA accumulation patterns of cell cycle-related genesShimizu, S.; Mori, H.
-
A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motifSoni, R.; Carmichael, J.P.; Shah, Z.H.; Murray, J.A.H.
-
Protein kinases and phosphatases and their role in cellular signaling in plantsSopory, S.K.; Munshi, M.
-
Distinct cyclin D genes show mitotic accumulation or constant levels of transcripts in tobacco bright yellow-2 cellsSorrell, D.A.; Combettes, B.; Chaubet-Gigot, N.; Gigot, C.; Murray, J.A.H.
-
Characterization of maize (Zea mays L.) Wee1 and its activity in developing endospermSun, Y.J.; Dilkes, B.P.; Zhang, C.S.; Dante, R.A.; Carneiro, N.P.; Lowe, K.S.; Jung, R.; Gordon-Kamm, W.J.; Larkins, B.A.
-
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin CTassan, J.P.; Jaquenoud, M.; Leopold, P.; Schultz, S.J.; Nigg, E.A.
-
Civ1 (CAK in vivo), a novel Cdk-activating kinaseThuret, J.Y.; Valay, J.G.; Faye, G.; Mann, C.
-
Cell cycle regulation by plant growth regulators: involvement of auxin and cytokinin in the re-entry of Petunia protoplasts into the cell cycleTrehin, C.; Planchais, S.; Glab, N.; Perennes, C.; Tregear, J.; Bergounioux, C.
-
A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thalianaUmeda, M.; Bhalerao, R.P.; Schell, J.; Uchimiya, H.; Koncz, C.
-
Differential expression of genes for cyclindependent protein kinases in rice plantsUmeda, M.; Umedahara, C.; Yamaguchi, M.; Hashimoto, J.; Uchimiya, H.
-
A plant cyclindependent kinase inhibitor geneWang, H.; Fowke, L.C.; Crosby, W.L.
-
ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis thaliana interacts with both Cdc2a and CycD3, and its expression is induced by abscisic acidWang, H.; Qi, Q.G.; Schorr, P.; Cutler, A.J.; Crosby, W.L.; Fowke, L.C.
-
Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteinsXie, Q.; Sanzburgos, P.; Hannon, G. J.; Gutierrez, C.
-
A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase IIYamaguchi, M.; Umeda, M.; Uchimiya, H.
@Phil_Robichaud
@deepthiw
@JoseServera