Caspase-independent apoptotic pathways in T lymphocytes: A minireview

Caspase-independent apoptotic pathways in T lymphocytes: A minireview Cell death by apoptosis is involved in the maintenance of T cell receptor diversity, self tolerance, and T-cell number homeostasis. Until recently, apoptosis was thought to require caspase activation. Evidence is now accumulating that a caspase-independent pathway exists, shown by in vitro experiments with broad-range caspase inhibitors. Mature T lymphocytes readily undergo caspase-independent apoptosis in vitro, and recent data suggest that this type of apoptosis may be involved in the negative selection of thymocytes. Mitochondria likely release death triggers specific for both caspase-dependent and caspase-independent apoptotic pathways (cytochrome c and AIF respectively) in response to apoptotic stimuli. A caspase-independent pathway is triggered first in activated T lymphocytes subjected to apoptotic stimuli that do not rely on receptors with death domains. In this pathway, the early commitment phase to apoptosis involves cell shrinkage, peripheral DNA condensation and the translocation of mitochondrial AIF to the cytosol and nucleus. This process is reversible until mitochondrial cytochrome c is released and ΔΨm dissipated. Only at this stage are caspases activated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Apoptosis Springer Journals

Caspase-independent apoptotic pathways in T lymphocytes: A minireview

Apoptosis, Volume 6 (5) – Oct 19, 2004

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Publisher
Springer Journals
Copyright
Copyright © 2001 by Kluwer Academic Publishers
Subject
Medicine & Public Health; Cancer Research; Virology; Anatomy; Oncology; Biochemistry, general
ISSN
1360-8185
eISSN
1573-675X
DOI
10.1023/A:1011390103783
Publisher site
See Article on Publisher Site

Abstract

Cell death by apoptosis is involved in the maintenance of T cell receptor diversity, self tolerance, and T-cell number homeostasis. Until recently, apoptosis was thought to require caspase activation. Evidence is now accumulating that a caspase-independent pathway exists, shown by in vitro experiments with broad-range caspase inhibitors. Mature T lymphocytes readily undergo caspase-independent apoptosis in vitro, and recent data suggest that this type of apoptosis may be involved in the negative selection of thymocytes. Mitochondria likely release death triggers specific for both caspase-dependent and caspase-independent apoptotic pathways (cytochrome c and AIF respectively) in response to apoptotic stimuli. A caspase-independent pathway is triggered first in activated T lymphocytes subjected to apoptotic stimuli that do not rely on receptors with death domains. In this pathway, the early commitment phase to apoptosis involves cell shrinkage, peripheral DNA condensation and the translocation of mitochondrial AIF to the cytosol and nucleus. This process is reversible until mitochondrial cytochrome c is released and ΔΨm dissipated. Only at this stage are caspases activated.

Journal

ApoptosisSpringer Journals

Published: Oct 19, 2004

References

  • Cross-talk in death signaling
    Roy, S; NicholsonW
  • The effect of caspase-inhibitors on radiation induced apoptosis in human peripheral blood lymphocytes: An electron microscopic approach
    Cornelissen, M; Vral, A; Thierens, H; de Ridder, L.
  • Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus
    Alam, A; Braun, MY; Hartgers, F
  • Blocked negative selection of developping T cells in mice expressing the baculovirus p35 caspase inhibitor
    Izquierdo, M; Grandien, A; Criado, LM

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