Caspase-dependent and -independent death pathways in cancer therapy

Caspase-dependent and -independent death pathways in cancer therapy The majority of current anticancer therapies induce tumor cell death through the induction of apoptosis. Alterations in the apoptotic pathways may determine tumor resistance to these therapies. Activation of the proteolytic cascade involving caspase family members is a critical component of the execution of cell death in apoptotic cells. However, recent studies suggest that cell death can proceed in the absence of caspases. In this review we describe the role of caspase-dependent and -independent pathways as targets for anticancer treatment; better understanding of diverse modes of tumor cell death will help to avoid ineffective treatment and provide a molecular basis for the new strategies targeting caspase-independent death pathways in apoptosis-resistant forms of cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Apoptosis Springer Journals

Caspase-dependent and -independent death pathways in cancer therapy

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Publisher
Springer Journals
Copyright
Copyright © 2000 by Kluwer Academic Publishers
Subject
Medicine & Public Health; Cancer Research; Virology; Anatomy; Oncology; Biochemistry, general
ISSN
1360-8185
eISSN
1573-675X
D.O.I.
10.1023/A:1009677307458
Publisher site
See Article on Publisher Site

Abstract

The majority of current anticancer therapies induce tumor cell death through the induction of apoptosis. Alterations in the apoptotic pathways may determine tumor resistance to these therapies. Activation of the proteolytic cascade involving caspase family members is a critical component of the execution of cell death in apoptotic cells. However, recent studies suggest that cell death can proceed in the absence of caspases. In this review we describe the role of caspase-dependent and -independent pathways as targets for anticancer treatment; better understanding of diverse modes of tumor cell death will help to avoid ineffective treatment and provide a molecular basis for the new strategies targeting caspase-independent death pathways in apoptosis-resistant forms of cancer.

Journal

ApoptosisSpringer Journals

Published: Oct 1, 2004

References

  • Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis
    Hirata, H; Takahashi, A; Kobayashi, S
  • Two CD95 (APO-1/Fas) signaling pathways
    Scaffidi, C; Fulda, S; Srinivasan, A
  • Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during
    Ferrari, D; Stepczynska, A; Los, M; Wesselborg, S; Schulze-Osthoff, K.
  • Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression
    Koshiji, M; Adachi, Y; Sogo, S

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