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Cannabinoids for Neuropathic Pain

Cannabinoids for Neuropathic Pain Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Pain and Headache Reports Springer Journals

Cannabinoids for Neuropathic Pain

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Pain Medicine; Internal Medicine
ISSN
1531-3433
eISSN
1534-3081
DOI
10.1007/s11916-014-0451-2
pmid
25160710
Publisher site
See Article on Publisher Site

Abstract

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain.

Journal

Current Pain and Headache ReportsSpringer Journals

Published: Aug 28, 2014

References