Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Kett, É. Azoulay, P. Echeverria, J. Vincent (2011)
Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*Critical Care Medicine, 39
L. Ostrosky-Zeichner, P. Pappas, S. Shoham, A. Reboli, M. Barron, C. Sims, C. Wood, J. Sobel (2011)
Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unitMycoses, 54
P. Eggimann, J. Garbino, D. Pittet (2003)
Epidemiology of Candida species infections in critically ill non-immunosuppressed patients.The Lancet. Infectious diseases, 3 11
D. Andes, N. Safdar, J. Baddley, G. Playford, A. Reboli, J. Rex, J. Sobel, P. Pappas, B. Kullberg (2012)
Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54 8
A. Shorr, Y. Tabak, R. Johannes, Xiaowu Sun, J. Spalding, M. Kollef (2009)
Candidemia on presentation to the hospital: development and validation of a risk scoreCritical Care, 13
G. Dimopoulos, A. Antonopoulou, A. Armaganidis, J. Vincent (2013)
How to select an antifungal agent in critically ill patients.Journal of critical care, 28 5
Priya Uppuluri, A. Srinivasan, Anand Ramasubramanian, J. Lopez-Ribot (2011)
Effects of Fluconazole, Amphotericin B, and Caspofungin on Candida albicans Biofilms under Conditions of Flow and on Biofilm DispersionAntimicrobial Agents and Chemotherapy, 55
Anand Kumar, P. Ellis, Y. Arabi, D. Roberts, B. Light, J. Parrillo, P. Dodek, G. Wood, Aseem Kumar, D. Simon, C. Peters, Muhammad Ahsan, D. Chateau (2009)
Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock.Chest, 136 5
Angela Huang, D. Newton, Anjly Kunapuli, Tejal Gandhi, L. Washer, Jacqueline Isip, C. Collins, J. Nagel (2013)
Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57 9
H. Wisplinghoff, H. Wisplinghoff, H. Seifert, R Wenzel, Michael Edmond (2006)
Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 12 2
Y. Skrobik, M. Laverdière (2013)
Why Candida sepsis should matter to ICU physicians.Critical care clinics, 29 4
M. Zilberberg, S. Kothari, A. Shorr (2009)
Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulationCritical Care, 13
D. Kett, A. Shorr, A. Reboli, A. Reisman, P. Biswas, H. Schlamm (2011)
Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: Support for the 2009 IDSA treatment guidelines for candidiasisCritical Care, 15
S. Hadley, Winnie Lee, R. Ruthazer, S. Nasraway (2002)
Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patientsCritical Care Medicine, 30
C. Marinach-Patrice, A. Fekkar, R. Atanasova, Johanna Gomes, Laura Djamdjian, J. Brossas, I. Meyer, P. Buffet, G. Snounou, A. Datry, C. Hennequin, J. Golmard, D. Mazier (2010)
Rapid Species Diagnosis for Invasive Candidiasis Using Mass SpectrometryPLoS ONE, 5
G. Patel, D. Simon, M. Scheetz, C. Crank, T. Lodise, N. Patel (2009)
The Effect of Time to Antifungal Therapy on Mortality in Candidemia Associated Septic ShockAmerican Journal of Therapeutics, 16
Y. Kaneko, Susumu Miyagawa, On Takeda, Masateru Hakariya, S. Matsumoto, H. Ohno, Y. Miyazaki (2013)
Real-Time Microscopic Observation of Candida Biofilm Development and Effects Due to Micafungin and FluconazoleAntimicrobial Agents and Chemotherapy, 57
M. Nucci, E. Anaissie, R. Betts, B. Dupont, Chunzhang Wu, D. Buell, L. Kovanda, O. Lortholary (2010)
Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 51 3
J. Garnacho-Montero, A. Díaz-Martín, E. García-Cabrera, M. Pipaón, C. Hernández-Caballero, J. Lepe-Jiménez (2013)
Impact on hospital mortality of catheter removal and adequate antifungal therapy in Candida spp. bloodstream infections.The Journal of antimicrobial chemotherapy, 68 1
A. Schuetz (2013)
Invasive fungal infections: biomarkers and molecular approaches to diagnosis.Clinics in laboratory medicine, 33 3
B. Posteraro, G. Pascale, M. Tumbarello, R. Torelli, M. Pennisi, G. Bello, R. Maviglia, G. Fadda, M. Sanguinetti, M. Antonelli (2011)
Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization indexCritical Care, 15
M. Bassetti, M. Marchetti, A. Chakrabarti, S. Colizza, J. Garnacho-Montero, D. Kett, P. Muñoz, F. Cristini, Anastasia Andoniadou, P. Viale, G. Rocca, E. Roilides, G. Sganga, T. Walsh, C. Tascini, M. Tumbarello, F. Menichetti, E. Righi, C. Eckmann, C. Viscoli, A. Shorr, O. Leroy, G. Petrikos, Francesco Rosa (2013)
A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational expertsIntensive Care Medicine, 39
H. Wisplinghoff, T. Bischoff, S. Tallent, H. Seifert, R. Wenzel, M. Edmond (2004)
Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 39 3
Marieke Roskes, C. Dreu, B. Nijstad (2012)
Necessity is the mother of invention: avoidance motivation stimulates creativity through cognitive effort.Journal of personality and social psychology, 103 2
L. Ostrosky-Zeichner, C. Sable, J. Sobel, B. Alexander, G. Donowitz, V. Kan, C. Kauffman, D. Kett, R. Larsen, V. Morrison, M. Nucci, P. Pappas, M. Bradley, S. Major, L. Zimmer, D. Wallace, W. Dismukes, J. Rex (2007)
Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care settingEuropean Journal of Clinical Microbiology & Infectious Diseases, 26
J. Guzman, Ronny Tchokonte, J. Sobel (2011)
Septic Shock Due to Candidemia: Outcomes and Predictors of Shock DevelopmentJournal of Clinical Medicine Research, 3
L. Ostrosky-Zeichner (2013)
Candida glabrata and FKS mutations: witnessing the emergence of the true multidrug-resistant Candida.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56 12
MG Schuster, JJE Edwards, JD Sobel, RO Darouiche, AW Karchmer, S Hadley (2008)
Empirical fluconazole versus placebo for intensive care unit patients: a randomized trialAnn Intern Med, 149
Gordon Brown, David Denning, Neil Gow, S. Levitz, M. Netea, Theodore White (2012)
Hidden Killers: Human Fungal InfectionsScience Translational Medicine, 4
C. Clancy, M. Nguyen (2012)
The end of an era in defining the optimal treatment of invasive candidiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54 8
B. Dupont, O. Lortholary, L. Ostrosky-Zeichner, F. Stucker, V. Yeldandi (2009)
Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin BCritical Care, 13
A. Guarascio, D. Slain, Richard McKnight, K. Petros, J. Parker, Alison Wilson, Carrie Defazio, A. Sarwari (2013)
A matched-control evaluation of an antifungal bundle in the intensive care unit at a university teaching hospitalInternational Journal of Clinical Pharmacy, 35
M. Schuster, J. Edwards, J. Sobel, R. Darouiche, A. Karchmer, S. Hadley, G. Slotman, H. Panzer, P. Biswas, J. Rex (2008)
Empirical Fluconazole versus Placebo for Intensive Care Unit PatientsAnnals of Internal Medicine, 149
L. Ostrosky-Zeichner (2012)
Invasive mycoses: diagnostic challenges.The American journal of medicine, 125 1 Suppl
Allen Antworth, C. Collins, Anjly Kunapuli, Kristin Klein, P. Carver, T. Gandhi, L. Washer, J. Nagel (2013)
Impact of an Antimicrobial Stewardship Program Comprehensive Care Bundle on Management of CandidemiaPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 33
W. Meersseman, K. Lagrou, I. Spriet, J. Maertens, E. Verbeken, W. Peetermans, E. Wijngaerden (2009)
Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy studyIntensive Care Medicine, 35
M. Zilberberg, M. Kollef, H. Arnold, Andrew Labelle, S. Micek, S. Kothari, A. Shorr (2010)
Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort studyBMC Infectious Diseases, 10
K. Hanson, C. Pfeiffer, E. Lease, A. Balch, A. Zaas, J. Perfect, B. Alexander (2012)
β-D-glucan Surveillance with Preemptive Anidulafungin for Invasive Candidiasis in Intensive Care Unit Patients: A Randomized Pilot StudyPLoS ONE, 7
F. Tissot, F. Lamoth, P. Hauser, C. Orasch, U. Flückiger, M. Siegemund, S. Zimmerli, T. Calandra, J. Billé, P. Eggimann, O. Marchetti (2013)
β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis.American journal of respiratory and critical care medicine, 188 9
Ping Liu, M. Ruhnke, W. Meersseman, J. Paiva, M. Kantecki, B. Damle (2013)
Pharmacokinetics of Anidulafungin in Critically Ill Patients with Candidemia/Invasive CandidiasisAntimicrobial Agents and Chemotherapy, 57
O. Jansoniene, M. White (2013)
β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Necessity is the mother of invention.American journal of respiratory and critical care medicine, 188 9
B. Pauw, Thomas Walsh, J. Donnelly, David A. Stevens, John E. Edwards, T. Calandra, Peter Pappas, J. Maertens, O. Lortholary, Carol Kauffman, D. Denning, Thomas Patterson, G. Maschmeyer, J. Billé, W. Dismukes, R. Herbrecht, William Hope, C. Kibbler, B. Kullberg, K. Marr, P. Muñoz, F. Odds, J. Perfect, Á. Restrepo, M. Ruhnke, B. Segal, Jack Sobel, Tania Sorrell, C. Viscoli, J. Wingard, T. Zaoutis, John E. Bennett (2008)
Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 46 12
H. Muskett, Jason Shahin, Gavin Eyres, Sheila Harvey, Kathy Rowan, David Harrison (2011)
Risk factors for invasive fungal disease in critically ill adult patients: a systematic reviewCritical Care, 15
M. Pfaller, S. Messer, Gary Moet, Ronald Jones, M. Castanheira (2011)
Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009).International journal of antimicrobial agents, 38 1
C. Clancy, M. Nguyen (2013)
Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56 9
B. Alexander, Melissa Johnson, C. Pfeiffer, Cristina Jimenez-Ortigosa, J. Catania, R. Booker, M. Castanheira, S. Messer, D. Perlin, M. Pfaller (2013)
Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56 12
Ping Liu (2012)
Population Pharmacokinetic-Pharmacodynamic Analysis of Anidulafungin in Adult Patients with Fungal InfectionsAntimicrobial Agents and Chemotherapy, 57
M. Climo, D. Yokoe, D. Warren, T. Perl, M. Bolon, L. Herwaldt, R. Weinstein, K. Sepkowitz, J. Jernigan, K. Sanogo, E. Wong (2013)
Effect of daily chlorhexidine bathing on hospital-acquired infection.The New England journal of medicine, 368 6
T. Avni, L. Leibovici, M. Paul (2010)
PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-AnalysisJournal of Clinical Microbiology, 49
S. Opal, G. Garber, S. LaRosa, D. Maki, R. Freebairn, G. Kinasewitz, J. Dhainaut, S. Yan, Mark Williams, D. Graham, D. Nelson, H. Levy, G. Bernard (2003)
Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 37 1
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Subgroup (2013)
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012Intensive Care Medicine, 39
D. Karageorgopoulos, E. Vouloumanou, F. Ntziora, A. Michalopoulos, P. Rafailidis, M. Falagas (2011)
β-D-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 52 6
M. Pfaller, S. Messer, Leah Woosley, Ronald Jones, M. Castanheira (2013)
Echinocandin and Triazole Antifungal Susceptibility Profiles for Clinical Opportunistic Yeast and Mold Isolates Collected from 2010 to 2011: Application of New CLSI Clinical Breakpoints and Epidemiological Cutoff Values for Characterization of Geographic and Temporal Trends of Antifungal ResistanceJournal of Clinical Microbiology, 51
DH Kett, E Azoulay, PM Echeverria, JL Vincent (2011)
Extended Prevalence of Infection in ICU Study (EPIC II) Group of Investigators. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study*Crit Care Med, 39
Siraya Jaijakul, J. Vázquez, R. Swanson, L. Ostrosky-Zeichner (2012)
(1,3)-β-D-glucan as a prognostic marker of treatment response in invasive candidiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 55 4
Juhsien Nienaber, S. Kusne, Talha Riaz, R. Walker, L. Baddour, A. Wright, Soon Park, H. Vikram, M. Keating, F. Arabía, B. Lahr, M. Sohail (2013)
Clinical manifestations and management of left ventricular assist device-associated infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57 10
L. Neely, M. Audeh, N. Phung, Michael Min, A. Suchocki, D. Plourde, M. Blanco, V. Demas, L. Skewis, T. Anagnostou, Jeffrey Coleman, P. Wellman, E. Mylonakis, T. Lowery (2013)
T2 Magnetic Resonance Enables Nanoparticle-Mediated Rapid Detection of Candidemia in Whole BloodScience Translational Medicine, 5
M. Kollef, S. Micek, Nicholas Hampton, Joshua Doherty, Anand Kumar (2012)
Septic shock attributed to Candida infection: importance of empiric therapy and source control.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54 12
É. Azoulay, H. Dupont, A. Tabah, O. Lortholary, J. Stahl, A. Français, Claude Martin, B. Guidet, J. Timsit (2012)
Systemic antifungal therapy in critically ill patients without invasive fungal infection*Critical Care Medicine, 40
P. Eggimann, J. Billé, O. Marchetti (2011)
Diagnosis of invasive candidiasis in the ICUAnnals of Intensive Care, 1
A. Lepak, D. Andes (2011)
Fungal sepsis: optimizing antifungal therapy in the critical care setting.Critical care clinics, 27 1
L Ostrosky-Zeichner (2013)
Editorial Commentary: Candida glabrata and FKS mutations: witnessing the emergence of the true multidrug-resistant CandidaClin Infect Dis, 56
O. Leroy, J. Gangneux, P. Montravers, J. Mira, F. Gouin, J. Sollet, J. Carlet, J. Reynes, M. Rosenheim, B. Régnier, O. Lortholary (2009)
Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005–2006)Critical Care Medicine, 37
F. Bloos, O. Bayer, S. Sachse, E. Straube, K. Reinhart, A. Kortgen (2013)
Attributable costs of patients with candidemia and potential implications of polymerase chain reaction-based pathogen detection on antifungal therapy in patients with sepsis.Journal of critical care, 28 1
D. Angus, T. Poll (2013)
Severe sepsis and septic shock.The New England journal of medicine, 369 9
Despite progress in the field of biological sciences, a definitive diagnosis of Candida sepsis remains an elusive target. Candida, which is frequently found in non-immunocompromised patients in intensive care units, causes severe sepsis, septic shock, and multiple-organ failure in a similar fashion as bacteria. Despite its imprecision, the blood and/or sterile-site culture is still the gold standard for diagnosis, although new biological markers are becoming available for earlier and more accurate diagnosis of invasive candidiasis. Mortality remains high due to a number of factors, and early initiation of appropriate antifungal therapy is a critical factor in positive outcomes. Echinocandins are the drug of choice for severe Candida infections in hospitalized patients. Antifungal stewardship programs may decrease the likelihood of resistance strains, and preventive measures are becoming available to lower the rate of fungal infections in intensive care units.
Current Fungal Infection Reports – Springer Journals
Published: Jan 12, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.