Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat

Bupropion enhances brain reward function and reverses the affective and somatic aspects of... Bupropion acts on multiple levels to alter brain reward circuits influenced by nicotine, in addition to reducing the expression of somatic signs of withdrawal. First, bupropion, unlike other antidepressants, increases brain reward function under baseline conditions in non-withdrawing subjects. Second, at low doses bupropion blocks the rewarding effects of nicotine. Third, bupropion reverses the negative affective aspects of nicotine withdrawal. Such actions are likely to act in concert to mediate the unique anti-smoking properties of bupropion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat

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Publisher
Springer Journals
Copyright
Copyright © 2003 by Springer-Verlag
Subject
Medicine
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-003-1445-7
Publisher site
See Article on Publisher Site

Abstract

Bupropion acts on multiple levels to alter brain reward circuits influenced by nicotine, in addition to reducing the expression of somatic signs of withdrawal. First, bupropion, unlike other antidepressants, increases brain reward function under baseline conditions in non-withdrawing subjects. Second, at low doses bupropion blocks the rewarding effects of nicotine. Third, bupropion reverses the negative affective aspects of nicotine withdrawal. Such actions are likely to act in concert to mediate the unique anti-smoking properties of bupropion.

Journal

PsychopharmacologySpringer Journals

Published: Jul 1, 2003

References

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