213 90 90 1 1 David M. Jackson Mayko Hashizume Department of Pharmacology The University of Sydney 2006 N.S.W. Australia Abstract In mice pretreated with reserpine plus alphamethyl- p -tyrosine, neither the D-2 selective agonist bromocriptine, nor the D-1 selective agonist SKF38393, produced any measurable increase in locomotion in mice. However, the combination of the two agonists produced a marked and dose-dependent increase in co-ordinated locomotor activity. In mice with their dopamine stores and dopamine synthesis intact, SKF38393 was inactive by itself, but significantly enhanced the stimulant effect produced by bromocriptine. The data suggest that bromocriptine requires concomitant stimulation of D-1 receptors for the full expression of its behavioural stimulant effects.
Psychopharmacology – Springer Journals
Published: Aug 1, 1986
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