221 79 79 2 2 S. G. P. Hardy S. M. Mack Department of Anatomy University of Mississippi Medical Center 39216 Jackson MS USA Summary Electrical stimulation of the prefrontal cortex (PFC) in rats produces transient hypotension. It has been suggested that this stimulus-produced hypotension (SPH) may be mediated by direct PFC projections to either the posterolateral hypothalamus or the nucleus tractus solitarius (NTS). To initially test these hypotheses, microinjections (0.5 μl) of 4% lidocaine were made into various brainstem sites, including the posterolateral hypothalamus, the PFC-NTS pathway and the NTS itself. Most injections made into the posterolateral hypothalamus, rostral portion of the PFC-NTS pathway or NTS were successful in blocking prefrontal SPH. In comparison, the majority of injections made into numerous other brainstem sites including the caudal portion of the PFC-NTS pathway did not block prefrontal SPH. These findings support the concept that prefrontal SPH maybe mediated via both the posterolateral hypothalamus and NTS. However, these findings do not support the hypothesis that prefrontal SPH is mediated by direct projections from the PFC to the NTS. To eliminate the possibility that the effects of the lidocaine injections made into the hypothalamus were due to the incapacitation of fibers alone, a series of experiments was conducted in which microinjections (0.5 μl) of ibotenic acid, a neurotoxin that destroys perikarya but spares axons, were made into the posterolateral hypothalamus. Each of these injections resulted in the blockade of prefrontal SPH. These findings further support the role of hypothalamic involvement in prefrontal SPH.
Experimental Brain Research – Springer Journals
Published: Jan 1, 1990
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera