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Bowel First? Simultaneous Resection? Liver First? Treatment options in patients with colorectal cancer and resectable synchronous liver metastases

Bowel First? Simultaneous Resection? Liver First? Treatment options in patients with colorectal... In patients with colorectal liver metastases surgical resection is the only potentially curative therapy option, with reported 5-year-survival of up to 50%. Approximately 25% of all patients with colorectal cancer have synchronous liver metastases, which has been associated with extremely poor prognosis. Advances in hepatic surgery and improved response rates to modern chemotherapeutic and targeted agents have changed our approach to stage IV patients from palliative therapy towards an aggressive multidisciplinary strategy in curative intention. However, the optimal treatment sequence in these patients has not been clearly defined. This short review summarizes the advantages and disadvantages of three different treatment approaches in patients with newly diagnosed colorectal cancer and resectable synchronous liver metastases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png memo - Magazine of European Medical Oncology Springer Journals

Bowel First? Simultaneous Resection? Liver First? Treatment options in patients with colorectal cancer and resectable synchronous liver metastases

Zitt, M.
memo - Magazine of European Medical Oncology , Volume 4 (2) – Jun 30, 2011
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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Medicine & Public Health; Medicine/Public Health, general; Oncology
ISSN
1865-5041
eISSN
1865-5076
DOI
10.1007/s12254-011-0261-8
Publisher site
See Article on Publisher Site

Abstract

In patients with colorectal liver metastases surgical resection is the only potentially curative therapy option, with reported 5-year-survival of up to 50%. Approximately 25% of all patients with colorectal cancer have synchronous liver metastases, which has been associated with extremely poor prognosis. Advances in hepatic surgery and improved response rates to modern chemotherapeutic and targeted agents have changed our approach to stage IV patients from palliative therapy towards an aggressive multidisciplinary strategy in curative intention. However, the optimal treatment sequence in these patients has not been clearly defined. This short review summarizes the advantages and disadvantages of three different treatment approaches in patients with newly diagnosed colorectal cancer and resectable synchronous liver metastases.

Journal

memo - Magazine of European Medical Oncology – Springer Journals

Published: Jun 30, 2011

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