Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it... In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable periods, such as foetal and neonatal life. The BPA source of contamination can occur via food, beverage, wastewater, air, dust and soil. BPA, as lipophilic compound, may accumulate into the adipose tissue already during foetal life and may affect adulthood health, through adverse effects on the growth and development of organs and tissues. Thus, based on several studies, it would be crucial to consider further actions aimed to refine risk assessment at least in vulnerable population, such as foetuses, infants and young children, to prevent metabolic diseases and obesity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinological Investigation Springer Journals

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?

Download PDF
5 pages

Loading next page...
 
/lp/springer-journals/bisphenol-a-environmental-exposure-and-the-detrimental-effects-on-JQFdWgd1t4
Publisher
Springer Journals
Copyright
Copyright © 2015 by The Author(s)
Subject
Medicine & Public Health; Medicine/Public Health, general; Endocrinology; Metabolic Diseases
eISSN
1720-8386
DOI
10.1007/s40618-015-0336-1
pmid
26105974
Publisher site
See Article on Publisher Site

Abstract

In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable periods, such as foetal and neonatal life. The BPA source of contamination can occur via food, beverage, wastewater, air, dust and soil. BPA, as lipophilic compound, may accumulate into the adipose tissue already during foetal life and may affect adulthood health, through adverse effects on the growth and development of organs and tissues. Thus, based on several studies, it would be crucial to consider further actions aimed to refine risk assessment at least in vulnerable population, such as foetuses, infants and young children, to prevent metabolic diseases and obesity.

Journal

Journal of Endocrinological Investigation – Springer Journals

Published: Jun 24, 2015

References

  • Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect
    Pereira-Fernandes, A; Demaegdt, H; Vandermeiren, K; Hectors, TL; Jorens, PG; Blust, R; Vanparys, C
  • Human exposure to bisphenol A (BPA)
    Vandenberg, LN; Hauser, R; Marcus, M; Olea, N; Welshons, WV
  • In vitro molecular mechanisms of bisphenol A action
    Wetherill, YB; Akingbemi, BT; Kanno, J; McLachlan, JA; Nadal, A; Sonnenschein, C; Watson, CS; Zoeller, RT; Belcher, SM
  • Bisphenol A and human health: a review of the literature
    Rochester, JR
  • Human exposure to bisphenol A
    Kang, JH; Kondo, F; Katayama, Y
  • Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure
    Liu, J; Yu, P; Qian, W; Li, Y; Zhao, J; Huan, F; Wang, J; Xiao, H
  • Handling of thermal receipts as a source of exposure to bisphenol A
    Ehrlich, S; Calafat, AM; Humblet, O; Smith, T; Hauser, R
  • Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population
    Savastano, S; Tarantino, G; D’Esposito, V; Passaretti, F; Cabaro, S; Liotti, A; Liguoro, D; Perruolo, G; Ariemma, F; Finelli, C; Beguinot, F; Formisano, P; Valentino, R
  • Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells
    Valentino, R; D’Esposito, V; Passaretti, F; Liotti, A; Cabaro, S; Longo, M; Perruolo, G; Oriente, F; Beguinot, F; Formisano, P
  • Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis
    Tarantino, G; Valentino, R; Somma, C; D’Esposito, V; Passaretti, F; Pizza, G; Brancato, G; Orio, V; Formisano, P; Colao, A; Savastano, S
  • Industrial endocrine disruptors and polycystic ovary syndrome
    Palioura, E; Diamanti-Kandarakis, E
  • Bisphenol-a treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life
    Alonso-Magdalena, P; García-Arévalo, M; Quesada, I; Nadal, Á
  • Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A
    Myers, JP; Vom Saal, FS; Akingbemi, BT; Arizono, K; Belcher, S; Colborn, T; Chahoud, I; Crain, DA; Farabollini, F; Guillette, LJ; Hassold, T; Ho, SM; Hunt, PA; Iguchi, T; Jobling, S; Kanno, J; Laufer, H; Marcus, M; McLachlan, JA; Nadal, A; Oehlmann, J; Olea, N; Palanza, P; Parmigiani, S; Rubin, BS; Schoenfelder, G; Sonnenschein, C; Soto, AM; Talsness, CE; Taylor, JA; Vandenberg, LN; Vandenbergh, JG; Vogel, S; Watson, CS; Welshons, WV; Zoeller, RT
  • Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes
    Rochester, JR; Bolden, AL