Biphasic effect of l -5-HTP in the Vogel conflict model

Biphasic effect of l -5-HTP in the Vogel conflict model 213 92 92 1 1 S. Hjorth B. Söderpalm J. A. Engel Department of Pharmacology University of Göteborg P.O. Box 33031 S-400 33 Göteborg Sweden Abstract The effect of l -5-HTP (25–400 mg/kg IP) following inhibition of the peripheral aromatic amino acid decarboxylase by means of benserazide (25 mg/kg IP) was investigated in a test modified from Vogel's drinking conflict model. At 50 mg/kg an anti-conflict action was detected, while higher doses (100–400 mg/kg) decreased punished responding. A lower dose (25 mg/kg) had no effect. Non-specific effects — such as alterations in muscle tone, in motivation to drink or in the sensitivity to electrical shock — could not explain the anxiolytic- and anxiogenic-like actions of 50 and 100 mg/kg, respectively. The bi-phasic effect of l -5-HTP is discussed in terms of different subpopulations of central serotoninergic receptors, possibly exerting opposing influences on conflict responding. The study emphasises the importance of 5-HT mechanisms in anxiety, and the possibility of finding novel anxiolytics among drugs selectively affecting central 5-HT neurotransmission. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Biphasic effect of l -5-HTP in the Vogel conflict model

Psychopharmacology, Volume 92 (1) – May 1, 1987

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Publisher
Springer Journals
Copyright
Copyright © 1987 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00215486
Publisher site
See Article on Publisher Site

Abstract

213 92 92 1 1 S. Hjorth B. Söderpalm J. A. Engel Department of Pharmacology University of Göteborg P.O. Box 33031 S-400 33 Göteborg Sweden Abstract The effect of l -5-HTP (25–400 mg/kg IP) following inhibition of the peripheral aromatic amino acid decarboxylase by means of benserazide (25 mg/kg IP) was investigated in a test modified from Vogel's drinking conflict model. At 50 mg/kg an anti-conflict action was detected, while higher doses (100–400 mg/kg) decreased punished responding. A lower dose (25 mg/kg) had no effect. Non-specific effects — such as alterations in muscle tone, in motivation to drink or in the sensitivity to electrical shock — could not explain the anxiolytic- and anxiogenic-like actions of 50 and 100 mg/kg, respectively. The bi-phasic effect of l -5-HTP is discussed in terms of different subpopulations of central serotoninergic receptors, possibly exerting opposing influences on conflict responding. The study emphasises the importance of 5-HT mechanisms in anxiety, and the possibility of finding novel anxiolytics among drugs selectively affecting central 5-HT neurotransmission.

Journal

PsychopharmacologySpringer Journals

Published: May 1, 1987

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