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John Lonstein, F. Denis, J. Perra, M. Pinto, Michael Smith, R. Winter (1999)
Complications associated with pedicle screws.The Journal of bone and joint surgery. American volume, 81 11
C. Lill, A. Fluegel, E. Schneider (2002)
Effect of Ovariectomy, Malnutrition and Glucocorticoid Application on Bone Properties in Sheep: A Pilot StudyOsteoporosis International, 13
A. Barbier, C. Martel, M. Vernejoul, F. Tirode, M. Nys, G. Mocaer, C. Morieux, H. Murakami, F. Lacheretz (1999)
The visualization and evaluation of bone architecture in the rat using three-dimensional X-Ray microcomputed tomographyJournal of Bone and Mineral Metabolism, 17
R. Wilkes, J. Mackinnon, W. Thomas (1994)
Neurological deterioration after cement injection into a vertebral body.The Journal of bone and joint surgery. British volume, 76 1
J. Lotz, Serena Hu, David Chiu, M. Yu, O. Colliou, R. Poser (1997)
Carbonated Apatite Cement Augmentation of Pedicle Screw Fixation in the Lumbar SpineSpine, 22
A. Turner, M. Alvis, W. Myers, M. Stevens, Mark Lundy (1995)
Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes.Bone, 17 4 Suppl
M. Richter, H. Wilke, P. Kluger, S. Neller, L. Claes, W. Puhl (2000)
Biomechanical evaluation of a new modular rod-screw implant system for posterior instrumentation of the occipito-cervical spine: in-vitro comparison with two established implant systemsEuropean Spine Journal, 9
M. Zarrinkalam, H. Beard, Christopher Schultz, Robert Moore (2009)
Validation of the sheep as a large animal model for the study of vertebral osteoporosisEuropean Spine Journal, 18
S. Cook, S. Salkeld, T. Whitecloud, J. Barberá (2000)
Biomechanical evaluation and preliminary clinical experience with an expansive pedicle screw design.Journal of spinal disorders, 13 3
J. Viljanen, H. Pihlajamäki, P. Törmälä, P. Rokkanen (1997)
Comparison of the tissue response to absorbable self‐reinforced polylactide screws and metallic screws in the fixation of cancellous bone osteotomies: An experimental study on the rabbit distal femurJournal of Orthopaedic Research, 15
Zi-xiang Wu, Wei Lei, Yun-yu Hu, Hai-qiang Wang, Shi-yong Wan, Zhen-sheng Ma, H. Sang, Suo-chao Fu, Yi-sheng Han (2008)
Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model.Medical engineering & physics, 30 9
V. Patel, A. Issever, A. Burghardt, A. Laib, M. Ries, S. Majumdar (2003)
MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimensJournal of Orthopaedic Research, 21
C. Turner, A. Chandran, R. Pidaparti (1995)
The anisotropy of osteonal bone and its ultrastructural implications.Bone, 17 1
E. Newman, A. Turner, J. Wark (1995)
The potential of sheep for the study of osteopenia: current status and comparison with other animal models.Bone, 16 4 Suppl
A. Turner (2002)
The sheep as a model for osteoporosis in humans.Veterinary journal, 163 3
M. Yamazaki, Tatsuo Shirota, Y. Tokugawa, Masayuki Motohashi, K. Ohno, K. Michi, Akira Yamaguchi (1999)
Bone reactions to titanium screw implants in ovariectomized animals.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 87 4
R. Gaines (2000)
The Use of Pedicle-Screw Internal Fixation for the Operative Treatment of Spinal Disorders*The Journal of Bone & Joint Surgery, 82
A. Laib, O. Barou, L. Vico, M. Lafage-Proust, C. Alexandre, P. Ruegsegger (2000)
3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosisMedical and Biological Engineering and Computing, 38
B. Bai, F. Kummer, J. Spivak (2001)
Augmentation of Anterior Vertebral Body Screw Fixation by an Injectable, Biodegradable Calcium Phosphate Bone SubstituteSpine, 26
C. Lill, Alexa Fluegel, Erich Schneider (2000)
Sheep model for fracture treatment in osteoporotic bone: a pilot study about different induction regimens.Journal of orthopaedic trauma, 14 8
Stephen Cook, Jose Barbera, Miguel Rubi, S. Salkeld, T. Whitecloud (2001)
Lumbosacral fixation using expandable pedicle screws. an alternative in reoperation and osteoporosis.The spine journal : official journal of the North American Spine Society, 1 2
M. Rohmiller, Dugan Schwalm, R. Glattes, Tarek Elalayli, D. Spengler (2002)
Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength.The spine journal : official journal of the North American Spine Society, 2 4
R. Brånemark, Lars‐Olof Öhrnell, P. Nilsson, P. Thomsen (1997)
Biomechanical characterization of osseointegration during healing: an experimental in vivo study in the rat.Biomaterials, 18 14
Torn Hirano, Kazuhiro Hasegawa, Toshikatsu Washio, Toshiaki Hara, Hideaki Takahashi (1998)
Fracture risk during pedicle screw insertion in osteoporotic spine.Journal of spinal disorders, 11 6
Mauz Jj (1995)
The effect of lumbar belts on isolated lumbar muscle.Spine, 20
H. Pihlajamäki, Pertti Myllynen, O. Böstman (1997)
Complications of transpedicular lumbosacral fixation for non-traumatic disorders.The Journal of bone and joint surgery. British volume, 79 2
Bernard Pfeifer, M. Krag, Chris Johnson (1994)
Repair of failed transpedicle screw fixation. A biomechanical study comparing polymethylmethacrylate, milled bone, and matchstick bone reconstruction.Spine, 19 3
S. Renner, T. Lim, W. Kim, L. Katolik, H. An, G. Andersson (2004)
Augmentation of Pedicle Screw Fixation Strength Using an Injectable Calcium Phosphate Cement as a Function of Injection Timing and MethodSpine, 29
M. Reinhold, K. Schwieger, J. Goldhahn, B. Linke, C. Knop, M. Blauth (2006)
Influence of Screw Positioning in a New Anterior Spine Fixator on Implant Loosening in Osteoporotic VertebraeSpine, 31
J. MacLeay, J. Olson, R. Enns, C. Les, C. Toth, D. Wheeler, A. Turner (2004)
Dietary-Induced Metabolic Acidosis Decreases Bone Mineral Density in Mature Ovariectomized EwesCalcified Tissue International, 75
P. Mummaneni, S. Haddock, M. Liebschner, T. Keaveny, W. Rosenberg (2002)
Biomechanical Evaluation of a Double-Threaded Pedicle Screw in Elderly VertebraeJournal of Spinal Disorders & Techniques, 15
S. Becker, A. Chavanne, R. Spitaler, K. Kropik, N. Aigner, M. Ogon, H. Redl (2008)
Assessment of different screw augmentation techniques and screw designs in osteoporotic spinesEuropean Spine Journal, 17
K. Leung, W. Siu, N. Cheung, P. Lui, D. Chow, A. James, L. Qin (2001)
Goats as an Osteopenic Animal ModelJournal of Bone and Mineral Research, 16
J. Jovanović, M. Lj. (2004)
BIOMECHANICAL MODEL OF VERTEBRA BASED ON BONE REMODELING
A. Milcan, Í. Ayan, A. Zeren, T. Sınmazçelik, A. Yılmaz, M. Zeren, F. Kuyurtar (2005)
Evaluation of Cyanoacrylate Augmentation of Transpedicular Screw Pullout StrengthJournal of Spinal Disorders & Techniques, 18
P. Fransen (2007)
Increasing pedicle screw anchoring in the osteoporotic spine by cement injection through the implant. Technical note and report of three cases.Journal of neurosurgery. Spine, 7 3
Wei Lei, Zi-xiang Wu (2006)
Biomechanical evaluation of an expansive pedicle screw in calf vertebraeEuropean Spine Journal, 15
Amy Kwok, J. Finkelstein, T. Woodside, T. Hearn, R. Hu (1996)
Insertional Torque and Pull‐out Strengths of Conical and Cylindrical Pedicle Screws in Cadaveric BoneSpine, 25
A. Ohlin, M. Karlsson, H. Düppe, R. Hasserius, I. Redlund‐Johnell (1994)
Complications After Transpedicular Stabilization of the Spine: A Survivorship Analysis of 163 CasesSPINE, 19
Transpedicular fixation can be challenging in the osteoporotic spine as reduced bone mineral density compromises the mechanical stability of the pedicle screw. Here, we sought to investigate the biomechanical and histological properties of stabilization of expandable pedicle screw (EPS) in the osteoporotic spine in sheep. EPSs and standard pedicle screws, SINO screws, were inserted on the vertebral bodies in four female ovariectomized sheep. Pull-out and cyclic bending resistance test were performed to compare the holding strength of these pedicle screws. High-resolution micro-computed tomography (CT) was performed for three-dimensional image reconstruction. We found that the EPSs provided a 59.6% increase in the pull-out strength over the SINO screws. Moreover, the EPSs withstood a greater number of cycles or load with less displacement before loosening. Micro-CT image reconstruction showed that the tissue mineral density, bone volume fraction, bone surface/bone volume ratio, trabecular thickness, and trabecular separation were significantly better in the expandable portion of the EPSs than those in the anterior portion of the SINO screws ( P < 0.05). Furthermore, the trabecular architecture in the screw–bone interface was denser in the expandable portion of the EPS than that in the anterior portion of the SINO screw. Histologically, newly formed bone tissues grew into the center of EPS and were in close contact with the EPS. Our results show that the EPS demonstrates improved biomechanical and histological properties over the standard screw in the osteoporotic spine. The EPS may be of value in treating patients with osteoporosis and warrants further clinical studies.
European Spine Journal – Springer Journals
Published: Dec 1, 2010
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