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Biocatalyzed transformation of progesterone by Geobacillus gargensis DSM 15378

Biocatalyzed transformation of progesterone by Geobacillus gargensis DSM 15378 The formation of secosteroids, 9,10-seco-4-pregnene-3,9,20-trione and 9,10-seco-4-pregnene-20α-hydroxy-3,9-dione, catalyzed by thermophilic bacterium Geobacillus gargensis DSM 15378 from progesterone is being reported for the first time. In addition, seven other hydroxy/keto progesterone derivatives, 7-ketoprogesterone, 11-ketoprogesterone, 20α-hydroxyprogesterone, 6β-hydroxyprogesterone, 6α-hydroxyprogesterone, 5α-pregnane-3,6,20-trione and 3β-hydroxy-5α-pregnane-6,20-dione, were identified through their spectral data. The influence of SDS, as a surfactant, on progesterone biotransformation products was investigated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Biocatalyzed transformation of progesterone by Geobacillus gargensis DSM 15378

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Life Sciences; Biochemistry, general; Microbiology; Medical Microbiology
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683815030023
Publisher site
See Article on Publisher Site

Abstract

The formation of secosteroids, 9,10-seco-4-pregnene-3,9,20-trione and 9,10-seco-4-pregnene-20α-hydroxy-3,9-dione, catalyzed by thermophilic bacterium Geobacillus gargensis DSM 15378 from progesterone is being reported for the first time. In addition, seven other hydroxy/keto progesterone derivatives, 7-ketoprogesterone, 11-ketoprogesterone, 20α-hydroxyprogesterone, 6β-hydroxyprogesterone, 6α-hydroxyprogesterone, 5α-pregnane-3,6,20-trione and 3β-hydroxy-5α-pregnane-6,20-dione, were identified through their spectral data. The influence of SDS, as a surfactant, on progesterone biotransformation products was investigated.

Journal

Applied Biochemistry and Microbiology – Springer Journals

Published: May 3, 2015

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